Antibodies against fetal brain in sera of mothers with autistic children

被引：109

作者：

Singer, Harvey S. ^{[1
]}

Morris, Christina M. ^{[1
]}

Gause, Colin D. ^{[1
]}

Gillin, Pam K. ^{[2
]}

Crawford, Stephen ^{[3
]}

Zimmerman, Andrew W. ^{[2
]}

机构：

[1] Johns Hopkins Univ Hosp, Dept Neurol, Baltimore, MD 21287 USA

[2] Ctr Autism & Related Disorders, Kennedy Krieger Inst, Baltimore, MD USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 194卷 / 1-2期

关键词：

autoimmunity; autistic disorder; maternal antibodies; GEAP; myelin basic protein; BDNF;

D O I：

10.1016/j.jneuroim.2007.11.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serum antibodies in 100 mothers of children with autistic disorder (MCAD) were compared to 100 age-matched mothers with unaffected children (MUC) using as antigenic substrates human and rodent fetal and adult brain tissues, GFAP, and MBP. MCAD had significantly more individuals with Western immunoblot bands at 36 kDa in human fetal and rodent embryonic brain tissue. The density of bands was greater in fetal brain at 61 kDa. MCAD plus developmental regression had greater reactivity against human fetal brain at 36 and 39 kDa. Data support a possible complex association between genetic/metabolie/environinental factors and the placental transfer of maternal antibodies in autism. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：165 / 172

页数：8

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