'PPAR'ting ways with inflammation

被引：40
作者：
Bailey, ST
Ghosh, S
机构：
[1] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06519 USA
[2] Yale Univ, Sch Med, Dept Mol Biophys & Biochem, New Haven, CT 06519 USA
来源：
NATURE IMMUNOLOGY | 2005年 / 6卷 / 10期
关键词：
D O I：
10.1038/ni1005-966
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Although it often acts as a transcriptional activator, the nuclear hormone receptor PPAR-gamma also `transrepresses' inflammatory responses mediated by the transcription factor NF-kappa B. New data demonstrate that sumoylation of PPAR-gamma leads to the retention of repressor complexes on promoters of inflammatory genes.
引用
收藏
页码：966 / 967
页数：3
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