'PPAR'ting ways with inflammation

被引：40

作者：

Bailey, ST

Ghosh, S

机构：

[1] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06519 USA

[2] Yale Univ, Sch Med, Dept Mol Biophys & Biochem, New Haven, CT 06519 USA

来源：

NATURE IMMUNOLOGY | 2005年 / 6卷 / 10期

关键词：

D O I：

10.1038/ni1005-966

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although it often acts as a transcriptional activator, the nuclear hormone receptor PPAR-gamma also `transrepresses' inflammatory responses mediated by the transcription factor NF-kappa B. New data demonstrate that sumoylation of PPAR-gamma leads to the retention of repressor complexes on promoters of inflammatory genes.

引用

收藏

页码：966 / 967

页数：3

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