miRNA deregulation in multiple myeloma

被引：7

作者：

Bi Chong Lei ^{[2
]}

Chng Wee Joo ^{[1
,2
,3
]}

机构：

[1] Natl Univ Hlth Syst, Natl Univ Canc Inst Singapore, Dept Hematol Oncol, Singapore 119228, Singapore

[2] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117548, Singapore

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 117595, Singapore

来源：

CHINESE MEDICAL JOURNAL | 2011年 / 124卷 / 19期

关键词：

miRNA; multiple myeloma; pathogenesis; genetics; chromosome; 13; CHRONIC LYMPHOCYTIC-LEUKEMIA; MICRORNA EXPRESSION; DOWN-REGULATION; PHARMACOLOGICAL ACTIVATION; UNDETERMINED SIGNIFICANCE; MONOCLONAL GAMMOPATHY; GENETIC EVENTS; BREAST-CANCER; CELL-LINES; PROFILES;

D O I：

10.3760/cma.j.issn.0366-6999.2011.19.037

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple myeloma (MM) is an incurable plasma cell malignancy and is the second most common hematological cancer. It is characterized by complex, recurrent genetic and epigenetic abnormalities. Recent publications have linked miRNAs, a novel class of gene regulators to cancer including MM. miRNAs are about 20 nucleotide, single strand, non-coding RNAs that repress gene expression by mRNA degradation or translational repression. Aberrant miRNA expression profiles have been described in MM, and their functional roles in MM pathogenesis are being increasingly recognized. This review summarizes the current literature on the role of miRNAs in MM and offers perspectives on future research and utilization of miRNAs in MM management. Chin Med J 2011;124(19):3164-3169

引用

页码：3164 / 3169

页数：6

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