Physiopathological Mechanism of Sarcopenia

被引：129
作者：
Walrand, Stephane [1 ,2 ]
Guillet, Christelle [1 ,2 ]
Salles, Jerome [1 ,2 ]
Cano, Noel [1 ,2 ,3 ]
Boirie, Yves [1 ,2 ,3 ]
机构：
[1] INRA, UMR 1019, UNH, CRNH Auvergne, F-63009 Clermont Ferrand, France
[2] Univ Clermont 1, UFR Med, UMR 1019, UNH, F-63001 Clermont Ferrand, France
[3] CHU Clermont Ferrand, Serv Nutr Clin, Hop Gabriel Montpied, F-63003 Clermont Ferrand, France
来源：
CLINICS IN GERIATRIC MEDICINE | 2011年 / 27卷 / 03期
关键词：
Sarcopenia; Nutrition; Exercise; Hormones; MUSCLE PROTEIN-SYNTHESIS; MYOSIN HEAVY-CHAIN; GROWTH-FACTOR-I; HUMAN SKELETAL-MUSCLE; TUMOR-NECROSIS-FACTOR; AGE-ADVANCED MEN; BODY-MASS INDEX; RESISTANCE EXERCISE; ELDERLY-MEN; AMINO-ACIDS;
D O I：
10.1016/j.cger.2011.03.005
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The etiology of sarcopenia is multifactorial but still poorly understood, and the sequelae of this phenomenon represent a major public health issue. Age-related loss of muscle mass can be counteracted by adequate metabolic interventions including nutritional intake and exercise training. Other strategies including changes in daily protein pattern, the speed of protein digestion, or specific amino acid supplementation may be beneficial to improve short-term muscle anabolic response in elderly people. A multimodal approach combining nutrition, exercise, hormones, and specific anabolic drugs may be an innovative treatment for limiting the development of sarcopenia with aging.
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收藏
页码：365 / +
页数：23
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