Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents

被引：26

作者：

Chi, Xiao-Qian ^{[1
,2
]}

Zi, Cheng-Ting ^{[3
]}

Li, Hong-Mei ^{[1
]}

Yang, Liu ^{[1
]}

Lv, Yong-Feng ^{[1
,2
]}

Li, Jin-Yu ^{[1
,2
]}

Hou, Bo ^{[1
,2
]}

Ren, Fu-Cai ^{[1
,2
]}

Hu, Jiang-Miao ^{[1
]}

Zhou, Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Yunnan Agr Univ, Coll Sci, Kunming 650201, Yunnan, Peoples R China

来源：

RSC ADVANCES | 2018年 / 8卷 / 72期

关键词：

ALPHA-MANGOSTIN; GARCINIA-MANGOSTANA; PRENYLATED XANTHONES; BIOLOGICAL EVALUATION; INHIBITORY-ACTIVITY; CELL-DEATH; DERIVATIVES; CONSTITUENTS; MECHANISM; CARCINOMA;

D O I：

10.1039/c8ra08409b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to better understand the structure-activity relationship of mangostin, a series of xanthone derivatives based on -mangostin were designed and synthesized. All the compounds were evaluated for their cytotoxicity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480) using MTT assays. Most of them showed cytotoxicity and most of all, compounds 1a and 2h showed the highest cytotoxic potency by HL-60 cancer cell lines with IC50 values of 5.96 M and 6.90 M respectively; compound 3e showed the highest cytotoxic potency against SMMC-7221 cancer cell line with IC50 values of 3.98 M; compounds 2e and 2m showed lower cytotoxicity but higher selectivity than -mangostin against HL-60 and SMMC-7221 cancer cell lines respectively. Structure-activity relationship analysis indicates that the maintenance of the isopentene group at C-8 is essential for the cytotoxic activity.

引用

页码：41377 / 41388

页数：12

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