Crystallization kinetics of citric acid anhydrate

被引：10

作者：

Nemdili, L. ^{[1
]}

Koutchoukali, O. ^{[1
]}

Bouhelassa, M. ^{[1
]}

Seidel, J. ^{[2
]}

Mameri, F. ^{[1
]}

Ulrich, J. ^{[2
]}

机构：

[1] Univ Constantine 3, Engn Fac Pharmaceut Proc, Nouvelle Ville Ali Mendjeli,BP 67A, Constantine, Algeria

[2] Univ Halle Wittenberg, Ctr Engn Sci, Thermal Proc Engn, D-06099 Halle, Saale, Germany

来源：

JOURNAL OF CRYSTAL GROWTH | 2016年 / 451卷

关键词：

Citric acid anhydrate; Metastable zone width; Primary nucleation; Growth rate; Crystallization; CRYSTAL-GROWTH KINETICS; METASTABLE ZONE WIDTHS; RAMAN-SPECTROSCOPY; POLYTHERMAL METHOD; IN-SITU; WATER; MONOHYDRATE; SOLUBILITY; NUCLEATION; SULFATE;

D O I：

10.1016/j.jcrysgro.2016.07.008

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The solubility curve, metastable zone width (MSZW) and Crystallization kinetics (nucleation and growth) were measured and estimated during batch crystallization of citric acid anhydrate (CAA). The solubility of citric acid in pure water was measured over the temperature range from 15 to 60 degrees C using a refractometer. The experimental data were correlated by the modified Apelblat equation. The MSZW was determined under four cooling rates for different citric acid concentrations by means of an ultrasonic technique. The primary nucleation kinetics of CAA was calculated based on these data and the poly thermal method of Nyvlt. It was found that the MSZW obtained is in good agreement with literature. Crystal growth rates were calculated by two methods. The first one used seeded isothermal growth experiments (desupersaturation curve) and the derivatives method of Garside. The second method used the measurement of the dimension change of a single crystal in a microscopic cell at different super saturation levels. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：88 / 94

页数：7

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