Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs)

被引：53
作者：
Curcio, Alberto [1 ]
Marotta, Roberto [1 ]
Riedinger, Andreas [1 ]
Palumberi, Domenico [1 ]
Falqui, Andrea [1 ]
Pellegrino, Teresa [1 ,2 ]
机构：
[1] Ist Italiano Tecnol, I-161613 Genoa, Italy
[2] CNR Nano, NNL, I-73100 Lecce, Italy
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 18期
关键词：
D O I：
10.1039/c2cc17223b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We here exploit pH-responsive nanogels as carriers to deliver functional anti-GFP siRNA and superparamagnetic IONPs to HeLa-GFP cells. The siRNA release via pH-mediated endosomal escape is shown. The IONPs act first as magnetofection agents to boost cellular uptake and then as probes to track the release mechanism by electron microscopy.
引用
收藏
页码：2400 / 2402
页数：3
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