An efficient, catalyst and solvent free Staudinger phosphite reaction for the synthesis of phosphoramidates under mild conditions

被引：1

作者：

Malik, Asif A. ^{[1
]}

Ara, Tabassum ^{[1
]}

机构：

[1] Natl Inst Technol NIT, Dept Chem, Srinagar 190006, Jammu & Kashmir, India

来源：

SYNTHETIC COMMUNICATIONS | 2022年 / 52卷 / 06期

关键词：

Aryl; benzyl azides; catalyst and solvent free; green protocol; phosphoramidates; INSECTICIDAL ACTIVITY; C-N; INHIBITORS; PHOSPHORYLATION; SOFOSBUVIR; CHEMISTRY; PROTEINS; ANALOG;

D O I：

10.1080/00397911.2022.2056851

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, catalyst-free and solvent-free protocol has been developed for the synthesis of phosphoramidates. This method can be used to synthesize phosphoramidates from diverse starting materials including aryl/benzyl and alkyl azides at room temperature. The synthesis is simple, selective and high yielding with notably a very short reaction time. The process involves mild reaction conditions which allow for sensitive functionalities and protecting groups to be used in the developed protocol that is of great advantage and could provide valuable reference for the construction of more complex heterocyclic linked phosphoramidate systems with biological and medicinal importance.

引用

页码：888 / 897

页数：10

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