Analysis of the network of feeding neuroregulators using the Allen Brain Atlas

被引:38
作者
Olszewski, Pawel K. [1 ,2 ]
Cedernaes, Jonathan
Olsson, Fredrik
Levine, Allen S. [2 ]
Schioth, Helgi B.
机构
[1] Uppsala Univ, Dept Neurosci, BMC, S-75124 Uppsala, Sweden
[2] Univ Minnesota, Dept Food Sci & Nutr, Minnesota Obes Ctr, St Paul, MN 55117 USA
关键词
CNS; food intake; obesity; anorexia; neuropeptides;
D O I
10.1016/j.neubiorev.2008.01.007
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The Allen Brain Atlas, the most comprehensive in situ hybridization database, covers over 21,000 genes expressed in the mouse brain. Here we discuss the feasibility to utilize the ABA in research pertaining to the central regulation of feeding and we define advantages and vulnerabilities associated with the use of the atlas as a guidance tool. We searched for 57 feeding-related genes in the ABA, and of those 42 display distribution consistent with that described in previous reports. Detailed analyses of these 42 genes in the nucleus accumbens, ventral tegmental area, nucleus of the solitary tract, lateral hypothalamus, arcuate, paraventricular, ventromedial and dorsomedial nuclei suggests that molecules involved in feeding stimulation and termination are coexpressed in multiple consumption-related sites. Gene systems linked to energy needs, reward or satiation display a remarkably high level of overlap. This conclusion calls into question the classical concept of brain sites viewed as independent hunger or reward "centers" and favors the theory of a widespread feeding network comprising multiple neuroregulators affecting numerous aspects of consumption. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:945 / 956
页数:12
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