High-dose methotrexate in patients with primary central nervous system lymphoma: does drug exposure really matter?

被引：2
作者：
Joerger, Markus [1 ]
Huitema, A. D. R. [2 ]
Illerhaus, G. [3 ]
Ferreri, A. J. M. [4 ]
机构：
[1] Cantonal Hosp, Dept Hematol & Oncol, CH-9007 St Gallen, Switzerland
[2] Slotervaart Hosp, Netherlands Canc Inst, Dept Pharm & Pharmacol, Amsterdam, Netherlands
[3] Univ Med Ctr, Dept Hematol & Oncol, Freiburg, Germany
[4] Ist Sci San Raffaele, Unit Lymphoid Malignancies, Dept Oncohematol, I-20132 Milan, Italy
来源：
LEUKEMIA & LYMPHOMA | 2011年 / 52卷 / 10期
关键词：
UNDER-THE-CURVE; TRIAL;
D O I：
10.3109/10428194.2011.580027
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：1825 / 1827
页数：3
相关论文
共 9 条
  • [1] Influence of methotrexate exposure on outcome in patients treated with MBVP chemotherapy for primary central nervous system lymphoma
    Blasco, Helene
    Senecal, Delphine
    Le Gouge, Amelie
    Pinard, Emmanuelle
    Benz-de Bretagne, Isabelle
    Colombat, Philippe
    Hulot, Jean-Sebastien
    Chatelut, Etienne
    Le Guellec, Chantal
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2010, 70 (03) : 367 - 375
  • [2] Area under the curve of methotrexate and creatinine clearance are outcome-determining factors in primary CNS lymphomas
    Ferreri, AJM
    Guerra, E
    Regazzi, M
    Pasini, F
    Arnbrosetti, A
    Pivnik, A
    Gubkin, A
    Calderoni, A
    Spina, M
    Brandes, A
    Ferrarese, F
    Rognone, A
    Govi, S
    Dell'Oro, S
    Locatelli, M
    Villa, E
    Reni, M
    [J]. BRITISH JOURNAL OF CANCER, 2004, 90 (02) : 353 - 358
  • [3] High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: a randomised phase 2 trial
    Ferreri, Andres J. M.
    Reni, Michele
    Foppoli, Marco
    Martelli, Maurizio
    Pangalis, Gerasimus A.
    Frezzato, Maurizio
    Cabras, Maria Giuseppina
    Fabbri, Alberto
    Corazzelli, Gaetano
    Ilariucci, Fiorella
    Rossi, Giuseppe
    Soffietti, Riccardo
    Stelitano, Caterina
    Vallisa, Daniele
    Zaja, Francesco
    Zoppegno, Lucia
    Aondio, Gian Marco
    Avvisati, Giuseppe
    Balzarotti, Monica
    Brandes, Alba A.
    Fajardo, Jose
    Gomez, Henry
    Guarini, Attilio
    Pinotti, Graziella
    Rigacci, Luigi
    Uhlmann, Catrina
    Picozzi, Piero
    Vezzulli, Paolo
    Ponzoni, Maurilio
    Zucca, Emanuele
    Caligaris-Cappio, Federico
    Cavalli, Franco
    [J]. LANCET, 2009, 374 (9700) : 1512 - 1520
  • [4] Individual fluorouracil dose adjustment based on pharmacokinetic follow-up compared with conventional dosage: Results of a multicenter randomized trial of patients with metastatic colorectal cancer
    Gamelin, Erick
    Delva, Remy
    Jacob, Jacques
    Merrouche, Yacine
    Raoul, Jean Luc
    Pezet, Denis
    Dorval, Etienne
    Piot, Gilles
    Morel, Alain
    Boisdron-Celle, Michele
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (13) : 2099 - 2105
  • [5] Rapid infusion of high-dose methotrexate resulting in enhanced penetration into cerebrospinal fluid and intensified tumor response in primary central nervous system lymphomas
    Hiraga, S
    Arita, N
    Ohnishi, T
    Kohmura, E
    Yamamoto, K
    Oku, Y
    Taki, T
    Sato, M
    Aozasa, K
    Yoshimine, T
    [J]. JOURNAL OF NEUROSURGERY, 1999, 91 (02) : 221 - 230
  • [6] Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma: A pharmacokinetic-pharmacodynamic analysis from the IELSG no. 20 trial
    Joerger, M.
    Huitema, A. D. R.
    Kraehenbuehl, S.
    Schellens, J. H. M.
    Cerny, T.
    Reni, M.
    Zucca, E.
    Cavalli, F.
    Ferreri, A. J. M.
    [J]. BRITISH JOURNAL OF CANCER, 2010, 102 (04) : 673 - 677
  • [7] Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study
    Larson, Richard A.
    Druker, Brian J.
    Guilhot, Francois
    O'Brien, Stephen G.
    Riviere, Gilles J.
    Krahnke, Tillmann
    Gathmann, Insa
    Wang, Yanfeng
    [J]. BLOOD, 2008, 111 (08) : 4022 - 4028
  • [8] Marcus R, 2007, GUIDELINES DIAGNOSIS
  • [9] Methotrexate area under the curve as a prognostic factor in primary central nervous system lymphoma treated with immunochemoradiotherapy
    Morris, Patrick G.
    Abrey, Lauren E.
    Reiner, Anne S.
    Wu, Nian
    Panageas, Katherine S.
    Seko, Brian S.
    Deangelis, Lisa M.
    Omuro, Antonio
    [J]. LEUKEMIA & LYMPHOMA, 2011, 52 (10) : 1891 - 1897
1