A Comparative Study of Site-Specific Distribution of Aging-Related Tau Astrogliopathy and Its Risk Factors Between Alzheimer Disease and Cognitive Healthy Brains: The Hisayama Study

被引：2

作者：

Yagita, Kaoru ^{[1
]}

Honda, Hiroyuki ^{[1
]}

Ohara, Tomoyuki ^{[2
,3
]}

Hamasaki, Hideomi ^{[1
]}

Koyama, Sachiko ^{[1
]}

Noguchi, Hideko ^{[1
]}

Mihara, Akane ^{[2
,3
]}

Nakazawa, Taro ^{[2
,3
]}

Hata, Jun ^{[3
,4
,5
]}

Ninomiya, Toshiharu ^{[3
,4
]}

Iwaki, Toru ^{[1
,3
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Neuropathol, Fukuoka 8128582, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Fukuoka, Japan

[3] Kyushu Univ, Grad Sch Med Sci, Dept Epidemiol & Publ Hlth, Fukuoka, Japan

[4] Kyushu Univ, Dept Ctr Cohort Studies, Grad Sch Med Sci, Fukuoka, Japan

[5] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2022年 / 81卷 / 02期

关键词：

Aging-related tau astrogliopathy; Alzheimer disease; Astrocyte; Olfactory nerve; Primary age-related tauopathy; PATHOLOGY; DEMENTIA; TRENDS; CORTEX;

D O I：

10.1093/jnen/nlab126

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Knowledge of aging-related tau astrogliopathy (ARTAG) in healthy elderly individuals remains incomplete and studies to date have not focused on the olfactory nerve, which is a vulnerable site of various neurodegenerative disease pathologies. We performed a semiquantitative evaluation of ARTAG in 110 autopsies in the Japanese general population (Hisayama study). Our analysis focused on Alzheimer disease (AD) and cognitive healthy cases (HC), including primary age-related tauopathy. Among the various diseased and nondiseased brains, ARTAG was frequently observed in the amygdala. The ARTAG of HC was exclusively limited to the amygdala whereas gray matter ARTAG in AD cases was prominent in the putamen and middle frontal gyrus following the amygdala. ARTAG of the olfactory nerve mainly consists of subpial pathology that was milder in the amygdala. A logistic regression analysis revealed that age at death and neurofibrillary tangle Braak stage significantly affected the ARTAG of HC. In AD, age at death and male gender had significant effects on ARTAG. In addition, the Thal phase significantly affected the presence of white matter ARTAG. In conclusion, our research revealed differences in the distribution of ARTAG and affected variables across AD and HC individuals.

引用

页码：106 / 116

页数：11

共 42 条

[1] Astrocytes produce CNTF during the remyelination phase of viral-induced spinal cord demyelination to stimulate FGF-2 production [J].