New triterpenoid saponins with strong α-glucosidase inhibitory activity from the roots of Gypsophila oldhamiana

被引：94

作者：

Luo, Han-Guang ^{[1
]}

Ma, Li ^{[1
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 06期

关键词：

Gypsophila oldhamiana; caryophyllaceae; triterpenoid saponins; alpha-glucosidase inhibitors;

D O I：

10.1016/j.bmc.2007.12.053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven new triterpenoid saponins (1-7), have been isolated and elucidated from the roots of Gypsophila oldhamiana together with five known triterpenoid saponins (8-12). These saponins which could be classified into three series: 3-O-monoglucosides (1, 8, 9), 28-O-monoglucosides (24, 12) and 3, 28-O-bidesmosides (5-7, 10, 11), have been evaluated for their a-glucosidase inhibition activity. As a result, the preliminary structure-activity relationships were discussed based on the position of sugar linkage attached to the aglycone, and 28-O-monoglucosides 2-4 and 12 showed significant inhibitory activities on a-glucosidase. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2912 / 2920

页数：9

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