Crossed cerebellar diaschisis in patients with cortical infarction - Logistic regression analysis to control for confounding effects

Background and Purpose - Crossed cerebellar diaschisis (CCD) refers to reduced metabolism and blood flow in the cerebellar hemisphere contralateral to a cerebral lesion. Many cortical areas have been reported to cause CCD without consideration of confounding factors. We performed single-photon emission computed tomography (SPECT) in patients with cortical infarction to identify regions independently related to CCD, controlling for possible confounding effects. Methods - Patients with unilateral cortical infarction (n=113; 75 male, 38 female; mean+/-SD age, 66+/-13 years) underwent SPECT of the brain with N-isopropyl-p-[I-123] iodoamphetamine (I-123-IMP). Regional cerebral blood flow was measured autoradiographically. Asymmetry indices (AIs) were calculated on the basis of ratios representing symmetrical regional cerebral blood flow in the cerebellum and 16 cerebral regions. CCD was defined as AI for cerebellum >0.1. AIs for 16 cortical regions were considered for both dichotomous and continuous variables for analysis of CCD occurrence by means of backward logistic regression. Results - For dichotomized variables, hypoperfusion of postcentral (odds ratio [OR] = 7.607; 95% CI, 2.299 to 25.174) and supramarginal (OR = 3.916; 95% CI, 1.394 to 11.003) regions independently influenced CCD. For continuous variables, hypoperfusion of postcentral (OR = 1.044; 95% CI, 1.019 to 1.068) and supramarginal (OR = 1.021; 95% CI, 1.001 to 1.041) regions (and, as a negative factor, medial occipital regions; OR = 0.942; 95% CI, 0.895 to 0.991) independently influenced CCD. Conclusions - Many cortical areas apparently do not contribute to CCD. Correspondence of CCD between dichotomized and continuous analyses suggests that location of a lesion, not severity, is the main determinant of CCD.