Ultrasmall natural peptides self-assemble to strong temperature-resistant helical fibers in scaffolds suitable for tissue engineering

被引：106

作者：

Mishra, Archana ^{[1
]}

Loo, Yihua ^{[1
]}

Deng, Renheng ^{[1
]}

Chuah, Yon Jin ^{[2
]}

Hee, Hwan Tak ^{[2
]}

Ying, Jackie Y. ^{[1
]}

Hauser, Charlotte A. E. ^{[1
]}

机构：

[1] The Nanos, Inst Bioengn & Nanotechnol, Singapore 138669, Singapore

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Orthoped Surg, Singapore 119228, Singapore

来源：

NANO TODAY | 2011年 / 6卷 / 03期

关键词：

Ultrasmall peptides; Self-assembly; Hydrogels; Tissue engineering; NUCLEUS PULPOSUS; HYDROGELS; BIOMATERIALS; MEDICINE; GELS;

D O I：

10.1016/j.nantod.2011.05.001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new class of systematically designed ultrasmall (tri- to heptamer) peptides presents the smallest natural, non-aromatic structures that self-assemble in water to hydrogels. The peptide motif consists of an aliphatic amino acid tail of decreasing hydrophobicity capped by a polar head. The fibrous scaffolds assemble from nanostructured aggregates to condensed three-dimensional (3D) meshes, entrapping up to 99.9% water and resembling collagen fibers in the extracellular matrix. The resulting hydrogels are biocompatible, heat resistant up to 90 degrees C and demonstrate tunable, high mechanical strength. Given their facile and cost-effective synthesis, these new materials would be attractive for applications ranging from injectable medical therapies to tissue-engineered scaffolds. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：232 / 239

页数：8

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