Protein and lipid sorting from the trans-Golgi network to the plasma membrane in polarized cells

被引:151
作者
Ikonen, E
Simons, K
机构
[1] Natl Publ Hlth Inst, Dept Biochem, SF-00300 Helsinki, Finland
[2] European Mol Biol Lab, Cell Biol Programme, D-69117 Heidelberg, Germany
[3] Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany
基金
芬兰科学院;
关键词
epithelial cell; lipid and protein transport; sorting signal-membrane raft;
D O I
10.1006/scdb.1998.0258
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The targeting of proteins and lipids to the cell surface domains of polarized cells is not a simple bulk flow process but requires sorting into distinct apical and basolateral pathways from the trans-Golgi network. Here, we describe the sorting determinants in the cargo molecules, the cellular sorting machineries responsible for the hierarchical read-out of the signals, and the mechanisms of cargo delivery. Furthermore, we discuss the implications of these findings for protein-lipid interactions in other cellular machineries.
引用
收藏
页码:503 / 509
页数:7
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