Controlled drug delivery vehicles for cancer treatment and their performance

被引：1640
作者：
Senapati, Sudipta [1 ]
Mahanta, Arun Kumar [1 ]
Kumar, Sunil [1 ]
Maiti, Pralay [1 ]
机构：
[1] Banaras Hindu Univ, Indian Inst Technol, Sch Mat Sci & Technol, Varanasi, Uttar Pradesh, India
来源：
SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2018年 / 3卷
关键词：
IRON-OXIDE NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; LAYERED DOUBLE HYDROXIDES; CALCIUM-PHOSPHATE NANOPARTICLES; TUMOR-TARGETED DELIVERY; BOVINE SERUM-ALBUMIN; ANTICANCER DRUG; CONTROLLED-RELEASE; QUANTUM DOTS; CARBON NANOTUBES;
D O I：
10.1038/s41392-017-0004-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.
引用
收藏
页数：19
相关论文
共 204 条
[1]   Tumor-targeted drug delivery systems based on supramolecular interactions between iron oxide-carbon nanotubes PAMAM-PEG-PAMAM linear-dendritic copolymers [J].
Adeli, Mohsen ;
Ashiri, Masoumeh ;
Chegeni, Beheshteh Khodadadi ;
Sasanpour, Pezhman .
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2013, 10 (04) :701-708
[2]   Theranostic applications of nanoparticles in cancer [J].
Ahmed, Naveed ;
Fessi, Hatem ;
Elaissari, Abdelhamid .
DRUG DISCOVERY TODAY, 2012, 17 (17-18) :928-934
[3]   Insights into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations [J].
Aime, S ;
Cabella, C ;
Colombatto, S ;
Crich, SG ;
Gianolio, E ;
Maggioni, F .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2002, 16 (04) :394-406
[4]   Cationic Poly-L-lysine Dendrimer Complexes Doxorubicin and Delays Tumor Growth in Vitro and in Vivo [J].
Al-Jamal, Khuloud T. ;
Al-Jamal, Wafa' T. ;
Wang, Julie T. -W. ;
Rubio, Noelia ;
Buddle, Joanna ;
Gathercole, David ;
Zloh, Mire ;
Kostarelos, Kostas .
ACS NANO, 2013, 7 (03) :1905-1917
[5]   Materials science - Smart biomaterials [J].
Anderson, DG ;
Burdick, JA ;
Langer, R .
SCIENCE, 2004, 305 (5692) :1923-1924
[6]   Characterization of biophysical and metabolic properties of cells labeled with superparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging [J].
Arbab, AS ;
Bashaw, LA ;
Miller, BR ;
Jordan, EK ;
Lewis, BK ;
Kalish, H ;
Frank, JA .
RADIOLOGY, 2003, 229 (03) :838-846
[7]   Enzyme-Triggered Disassembly of Dendrimer-Based Amphiphilic Nanocontainers [J].
Azagarsamy, Malar A. ;
Sokkalingam, Punidha ;
Thayumanavan, S. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (40) :14184-+
[8]   A study on sustained release formulations for oral delivery of 5-fluorouracil based on alginate-chitosan/montmorillonite nanocomposite systems [J].
Azhar, Fahimeh Farshi ;
Olad, Ali .
APPLIED CLAY SCIENCE, 2014, 101 :288-296
[9]   A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study [J].
Balivada, Sivasai ;
Rachakatla, Raja Shekar ;
Wang, Hongwang ;
Samarakoon, Thilani N. ;
Dani, Raj Kumar ;
Pyle, Marla ;
Kroh, Franklin O. ;
Walker, Brandon ;
Leaym, Xiaoxuan ;
Koper, Olga B. ;
Tamura, Masaaki ;
Chikan, Viktor ;
Bossmann, Stefan H. ;
Troyer, Deryl L. .
BMC CANCER, 2010, 10
[10]   Doxil® - The first FDA-approved nano-drug: Lessons learned [J].
Barenholz, Yechezkel .
JOURNAL OF CONTROLLED RELEASE, 2012, 160 (02) :117-134
12345678910