Influence of liquid coverage on the anticancer effects of a helium plasma jet on 3D tumor spheroids

被引：12

作者：

Zhang, Jishen ^{[1
]}

Liu, Dingxin ^{[1
]}

Zhang, Hao ^{[1
]}

Xia, Wenjie ^{[1
]}

Liu, Yifan ^{[1
]}

Sun, Bowen ^{[1
]}

Xu, Dehui ^{[1
]}

Guo, Li ^{[1
]}

Kong, Michael G. ^{[1
,2
,3
]}

机构：

[1] Xi An Jiao Tong Univ, Ctr Plasma Biomed, State Key Lab Elect Insulat & Power Equipment, Xian 710049, Shaanxi, Peoples R China

[2] Old Dominion Univ, Frank Reidy Ctr Bioelect, Norfolk, VA USA

[3] Old Dominion Univ, Dept Elect & Comp Engn, Norfolk, VA USA

来源：

PLASMA PROCESSES AND POLYMERS | 2020年 / 17卷 / 07期

基金：

中国国家自然科学基金;

关键词：

3D multicellular tumor spheroids; cancer therapy; cold atmospheric plasmas; liquid coverage; reactive oxygen species; BARRIER DISCHARGE PLASMA; COLD ATMOSPHERIC PLASMA; CELL-CULTURE; CANCER-CELLS; DEATH; HEAD; BIOLOGY;

D O I：

10.1002/ppap.201900213

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

In clinical treatment, the presence or absence of transudate coverage of exposed tumor tissue may have a significant impact on the therapeutic effect of cold atmospheric plasma. Here, the anticancer effects of a plasma jet on three-dimensional multicellular tumor spheroids with or without liquid coverage were examined. It was found that cell viability decreased more rapidly without liquid coverage than with liquid coverage. Apoptotic cells and reactive oxygen species (ROS) were mainly distributed in the areas of the spheroids directly irradiated by the plasma jet without liquid coverage. However, with liquid coverage, they were distributed throughout the outermost layers of the whole spheroids. Importantly, liquid can help ROS penetrate into spheroids and prolong the anticancer effects of plasma.

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页数：9

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