Palladium-catalyzed aryl-amidation.: Synthesis of non-racemic N-aryl lactams

被引：19

作者：

Browning, RG ^{[1
]}

Badarinarayana, V ^{[1
]}

Mahmud, H ^{[1
]}

Lovely, CJ ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Arlington, TX 76019 USA

来源：

TETRAHEDRON | 2004年 / 60卷 / 02期

基金：

美国国家科学基金会;

关键词：

pyrrolidinone; cross-coupling; catalysis;

D O I：

10.1016/j.tet.2003.11.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Buchwald/Hartwig aryl amination method was used to construct a series of chiral, non-racemic N-aryl pyrrolidinones from a common pyrrolidinone precursor and the corresponding aryl bromide. The stereochemical integrity of the N-aryl lactam after cross-coupling was proven by synthesis of the racemic compounds and comparison by H-1 NMR spectroscopy using Pirkle's chiral solvating agent. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：359 / 365

页数：7

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