Genome studies: Genetics by numbers

被引：12

作者：

Baker, Monya

机构：

来源：

NATURE | 2008年 / 451卷 / 7178期

关键词：

D O I：

10.1038/451516a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genomewide association studies are starting to turn up increasingly reliable disease markers. Single nucleotide polymorphisms or SNPs, are located close to one another on chromosome 9 which are involved in the development of heart diseases in a group of individuals. Carrying two copies of any of the genes boosts a person's chance of developing heart disease by the same amount as smoking ten cigarettes a day. The effect is less than that brought on by diabetes or heavier smoking, but it is still one of the strongest risks so far identified by genomewide association studies. Having one copy of any of the wrong SNPs boosts risk by about 40%. Genomewide association studies find SNPs, single letter changes in the genome, that appear commonly and may correlate to more variation in nearby DNA. SNPs are not necessarily the causative mutations. They might not even be in genecoding or gene-controlling regions, and thus may not contribute, even indirectly, to risk. The heart- risk SNPs indicate only that the culprit is located within a long genomic region on chromosome 9.

引用

页码：516 / 518

页数：3

共 15 条

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