Selenium-Binding Protein 1 in Human Health and Disease

被引:80
作者
Elhodaky, Mostafa [1 ]
Diamond, Alan M. [1 ]
机构
[1] Univ Illinois, Dept Pathol, Chicago, IL 60612 USA
基金
美国国家卫生研究院;
关键词
selenium-binding protein 1; SBP1; SELENBP1; hSP56; cancer; disease; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; GLUTATHIONE-PEROXIDASE; PROSTATE-CANCER; FACTOR; 1-ALPHA; HYDROGEN-SULFIDE; GENE-EXPRESSION; HEPATOCELLULAR-CARCINOMA; UNFAVORABLE PROGNOSIS; FACTORS HIF-1-ALPHA; OVARIAN-TUMORS;
D O I
10.3390/ijms19113437
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Selenium-binding protein 1 (SBP1) is a highly conserved protein that covalently binds selenium. SBP1 may play important roles in several fundamental physiological functions, including protein degradation, intra-Golgi transport, cell differentiation, cellular motility, redox modulation, and the metabolism of sulfur-containing molecules. SBP1 expression is often reduced in many cancer types compared to the corresponding normal tissues and low levels of SBP1 are frequently associated with poor clinical outcome. In this review, the transcriptional regulation of SBP1, the different physiological roles reported for SBP1, as well as the implications of SBP1 function in cancer and other diseases are presented.
引用
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页数:14
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