Are prophylactic antibiotics necessary with clean intermittent catheterization? A randomized controlled trial

Background/Purpose: Clean intermittent catheterization has been an established practice for more than 3 decades. The validity of antibiotic prophylaxis has been questioned although not tested. Methods: Eighty-five patients were recruited into a randomized controlled trial. The randomization involved the placement into 1of 2 groups: (A) continuing antibiotics or (13) discontinuing antibiotics. The trial would last 4 months with the outcome being a confirmed urinary tract infection. All groups were matched for age, sex, and pathology. Results: The incidence of urinary tract infections was significantly increased in the group who continued to use antibiotics (n = 20) when compared with the group who discontinued prophylaxis (n = 3). The common infecting organism was Escherichia coli. Conclusions: The use of prophylactic antibiotics for children who intermittently catheterize may not be necessary. The use of prophylactic antibiotics may result in increased rates of infection because of the development of resistant organisms. (c) 2005 Elsevier Inc. All rights reserved.