Current topics in autoimmune hepatitis

被引：15

作者：

Muratori, Luigi ^{[1
]}

Muratori, Paolo ^{[1
]}

Granito, Alessandro ^{[1
]}

Pappas, Giorgios ^{[1
]}

Cassani, Fabio ^{[1
]}

Lenzi, Marco ^{[1
]}

机构：

[1] Alma Mater Studiorum Univ Bologna, Dept Clin Med, Policlin St Orsola Malpighi, Bologna, Italy

来源：

DIGESTIVE AND LIVER DISEASE | 2010年 / 42卷 / 11期

关键词：

Autoantibodies; Autoimmune hepatitis; Diagnosis; Liver; Therapy; REGULATORY T-CELLS; SOLUBLE LIVER ANTIGEN; PRIMARY BILIARY-CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; CHRONIC ACTIVE HEPATITIS; NOVO IMMUNE HEPATITIS; S-TRANSFERASE T1; TERM-FOLLOW-UP; MYCOPHENOLATE-MOFETIL; OVERLAP SYNDROME;

D O I：

10.1016/j.dld.2010.05.019

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Autoimmune hepatitis is a chronic liver disease of unknown aetiology characterized by interface hepatitis, hypergammaglobulinaemia and circulating autoantibodies. In the last decade a number of advancements have been made in the field of clinical and basic research: the simplified diagnostic criteria, the complete response defined as normalization of transaminase levels, the molecular identification of the antigenic targets of anti-liver cytosol antibody type 1 and anti-soluble liver antigen, the detection of anti-actin antibodies, the description of de nova autoimmune hepatitis after liver transplantation for non-autoimmune liver diseases, the characterization of autoimmune hepatitis with overlapping features of primary biliary cirrhosis or primary sclerosing cholangitis, the preliminary experience with novel treatment strategies based on cyclosporine, mycophenolate mofetil and budesonide, the role played by "impaired" regulatory T cells and the development of novel animal models of autoimmune hepatitis. (C) 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：757 / 764

页数：8

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