A family of simple amide-derived air-stable P,O-ligands for Suzuki cross-coupling of unactivated aryl chlorides

被引：56

作者：

Dai, WM ^{[1
]}

Zhang, Y ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 08期

关键词：

amides; phosphines; Suzuki reaction; aryl chlorides;

D O I：

10.1016/j.tetlet.2004.12.133

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A family of air-stable amide-derived phosphine (Aphos) ligands engineered on simple N,N-dialkyl aryl amide scaffolds has been designed and prepared by one-pot synthesis from the amides in high yields. The Aphos ligands have been used, in analogous to their atropisomeric variations, as hemilabile bidentate P,O-ligands in various Pd-catalyzed C-N and C-C bond forming reactions. We present here our results on the highly efficient Suzuki cross-coupling reactions of unactivated and/or sterically hindered aryl chlorides with arylboronic acids and a relationship of Aphos structures with catalytic efficacy. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1377 / 1381

页数：5

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