ETV6-NTRK3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective TRK inhibition

被引：55

作者：

Roberts, Kathryn G. ^{[1
]}

Janke, Laura J. ^{[1
]}

Zhao, Yaqi ^{[1
]}

Seth, Aman ^{[2
]}

Ma, Jing ^{[1
]}

Finkelstein, David ^{[3
]}

Smith, Steve ^{[4
]}

Ebata, Kevin ^{[4
]}

Tuch, Brian B. ^{[4
]}

Hunger, Stephen P. ^{[5
,6
,7
]}

Mullighan, Charles G. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Pathol, 262 Danny Thomas Pl, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Chem Biol & Therapeut, 332 N Lauderdale St, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA

[4] Loxo Oncol, San Francisco, CA USA

[5] Univ Penn, Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[6] Univ Penn, Childrens Hosp Philadelphia, Ctr Childhood Res, Philadelphia, PA 19104 USA

[7] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

基金：

美国国家卫生研究院;

关键词：

GENE FUSION; KINASE; ETV6; ONCOGENE; EVENT; LINE;

D O I：

10.1182/blood-2018-05-849554

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：861 / 865

页数：5

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