Outcome of treatment of MDR-TB or drug-resistant patients treated with bedaquiline and delamanid: Results from a large global cohort

被引：40

作者：

Koirala, S. ^{[1
]}

Borisov, S. ^{[2
]}

Danila, E. ^{[3
]}

Mariandyshev, A. ^{[4
]}

Shrestha, B. ^{[5
]}

Lukhele, N. ^{[6
]}

Dalcolmo, M. ^{[7
]}

Shakya, S. R. ^{[8
]}

Miliauskas, S. ^{[9
]}

Kuksa, L. ^{[10
]}

Manga, S. ^{[11
]}

Aleksa, A. ^{[12
]}

Denholm, J. T. ^{[13
]}

Khadka, H. B. ^{[14
]}

Skrahina, A. ^{[15
]}

Diktanas, S. ^{[16
]}

Ferrarese, M. ^{[17
]}

Bruchfeld, J. ^{[18
,19
]}

Koleva, A. ^{[20
]}

Piubello, A.

Koirala, G. S. ^{[22
]}

Udwadia, Z. F. ^{[23
]}

Palmero, D. J. ^{[24
]}

Munoz-Torrico, M. ^{[25
]}

Gc, R. ^{[26
]}

Gualano, G. ^{[27
]}

Grecu, V., I ^{[28
]}

Motta, I ^{[29
]}

Papavasileiou, A. ^{[30
]}

Li, Y. ^{[31
]}

Hoefsloot, W. ^{[32
]}

Kunst, H. ^{[33
]}

Mazza-Stalder, J. ^{[34
]}

Payen, M-C ^{[35
]}

Akkerman, O. W. ^{[36
,37
]}

Bernal, E. ^{[38
]}

Manfrin, V ^{[39
]}

Matteelli, A. ^{[40
]}

Hamdan, H. Mustafa ^{[41
]}

Marcos, M. Nieto ^{[42
]}

Cadinanos Loidi, J. ^{[43
]}

Cebrian Gallardo, J. J. ^{[44
]}

Duarte, R. ^{[45
]}

Escobar Salinas, N. ^{[46
]}

Gomez Rosso, R. ^{[47
]}

Laniado-Laborin, R. ^{[48
,49
]}

Martinez Robles, E. ^{[50
]}

Quiros Fernandez, S. ^{[51
]}

Rendon, A. ^{[52
]}

Solovic, I ^{[53
]}

机构：

[1] Damien Fdn Nepal, Kathmandu, Nepal

[2] Moscow Govts Hlth Dept, Moscow Res & Clin Ctr TB Control, Moscow, Russia

[3] Vilnius Univ, Vilnius Univ Hosp Santaros Klin, Ctr Pulmonol & Allergol, Clin Chest Dis Immunol & Allergol,Med Fac, Vilnius, Lithuania

[4] Northern State Med Univ, Northern Arctic Fed Univ, Arkhangelsk, Russia

[5] Kalimati Chest Hosp, GENETUP, Nepal Anti TB Assoc, Kathmandu, Nepal

[6] World Hlth Org, TB HIV Hepatitis & PMTCT Dept, Eswatini WHO Country Off, Mbabane, Eswatini

[7] Minist Hlth, Fundacao Oswaldo Cruz Fiocruz, Reference Ctr Helio Fraga, Rio De Janeiro, Brazil

[8] Lumbini Prov Hosp, Butwal, Nepal

[9] Lithuanian Univ Hlth Sci, Dept Pulmonol, Kaunas, Lithuania

[10] Riga East Univ Hosp, MDR TB Dept, TB & Lung Dis Ctr, Riga, Latvia

[11] Univ Natl San Antonio Abad Cusco, Dept Infect Dis, Cuzco, Peru

[12] Grodno State Med Univ, Dept Phthisiol & Pulmonol, Grodno, BELARUS

[13] Univ Melbourne, Dept Infect Dis, Melbourne Hlth, Victorian TB Program, Melbourne, Vic, Australia

[14] TB Nepal, Nepalgjunj TB Referral Ctr, Nepalganj, Nepal

[15] Republican Res & Pract Ctr Pulmonol & TB, Minsk, BELARUS

[16] Republican Klaip Hosp, TB Dept, TB Unit 3, Klaipeda, Lithuania

[17] Osped Niguarda Ca Granda, TB Reference Ctr, Villa Marelli Inst, Milan, Italy

[18] Dept Med, Div Infect Dis, Solna, Sweden

[19] Karolinska Univ Hosp, Karolinska Inst, Dept Infect Dis, Stockholm, Sweden

[20] Gabrovo Lung Dis Hosp, Pulmonol & Physiotherapy Dept, Gabrovo, Bulgaria

[21] Damien Fdn, Niamey, Niger

[22] Nepal Anti TB Assoc, TB Clin, Morang Branch, Biratnagar 1, Nepal

[23] PD Hinduja Natl Hosp & MRC, Dept Resp Med, Mumbai, Maharashtra, India

[24] Municipal Hosp FJ Muniz, Pulmonol Div, Buenos Aires, DF, Argentina

[25] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Clin TB, Ciudad De Mexico, Mexico

[26] Midpoint Dist Community Mem Hosp, Damien Fdn, Danda, Nawalparasi, Nepal

[27] IRCCS, Resp Infect Dis Unit, Natl Inst Infect Dis L Spallanzani, Rome, Italy

[28] Natl Programme Prevent Surveillance & Control TB, Craiova, Dolj Province, Romania

[29] Univ Torino, Dept Med Sci, Unit Infect Dis, Turin, Italy

[30] Sotiria Athens Hosp Chest Dis, Dept TB, Athens, Greece

[31] Fudan Univ, Huashan Hosp, Dept Infect Dis, Shanghai, Peoples R China

[32] Radboud Univ Nijmegen Med Ctr, Ctr Dekkerswald, Nijmegen, Netherlands

[33] Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England

[34] Univ Hosp Lausanne CHUV, Div Pulm Med, Lausanne, Switzerland

[35] Univ Libre Bruxelles ULB, Div Infect Dis, CHU St Pierre, Brussels, Belgium

[36] Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Dis & TB, Groningen, Netherlands

[37] Univ Groningen, Univ Med Ctr Groningen, TB Ctr Beatrixoord, Haren, Netherlands

[38] Hosp Gen Univ Reina Sofia, Unidad Enfermedades Infecciosas, Murcia, Spain

[39] S Bortolo Hosp, Infect & Trop Dis Operating Unit, Vicenza, Italy

[40] Univ Brescia, WHO Collaborating Ctr TB Eliminat & TB HIV Coinfe, Clin Infect & Trop Dis, Brescia, Italy

[41] Abu Anga Teaching Hosp, MDR TB Dept, Khartoum, Sudan

[42] Hosp Doctor Moliner, Internal Med Dept, Valencia, Spain

[43] Hosp Gen Villalba, Internal Med Dept, Collado Villalba, Spain

[44] Agencia Sanitaria Costa del Sol, Unidad Neumol, Marbella, Spain

[45] Univ Porto, Hosp Ctr Vila Nova de Gaia, Fac Med, Natl Reference Ctr MDR TB,Dept Pneumol,Publ Hlth, Porto, Portugal

[46] Minist Hlth Santiago, Div Dis Prevent & Control, Dept Communicable Dis, Natl TB Control & Eliminat Programme, Santiago, Chile

[47] Natl Inst Resp & Environm Dis Prof Dr Juan Max Bo, Asuncion, Paraguay

[48] Univ Autonoma Baja California, Mexicali, Baja California, Mexico

[49] Hosp Gen Tijuana, Clin TB, Tijuana, Baja California, Mexico

[50] Hosp Gen Univ La Paz, Internal Med Dept, Hosp Cantoblanco, Madrid, Spain

来源：

PULMONOLOGY | 2021年 / 27卷 / 05期

关键词：

Tuberculosis; MDR-TB; Delamanid; Bedaquiline; Treatment outcomes; Prevention of TB sequelae; TUBERCULOSIS; REHABILITATION; ACCESS; EXPERIENCES; SEQUELAE; PROGRESS; NEED;

D O I：

10.1016/j.pulmoe.2021.02.006

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The World Health Organization (WHO) recommends countries introduce new anti-TB drugs in the treatment of multidrug-resistant tuberculosis. The aim of the study is to prospectively evaluate the effectiveness of bedaquiline (and/or delamanid)- containing regimens in a large cohort of consecutive TB patients treated globally. This observational, prospective study is based on data collected and provided by Global Tuberculosis Network (GTN) centres and analysed twice a year. All consecutive patients (including children/adolescents) treated with bedaquiline and/or delamanid were enrolled, and managed according to WHO and national guidelines. Overall, 52 centres from 29 countries/regions in all continents reported 883 patients as of January 31st 2021, 24/29 countries/regions providing data on 100% of their consecutive patients (10-80% in the remaining 5 countries). The drug-resistance pattern of the patients was severe (>30% with extensively drug-resistant -TB; median number of resistant drugs 5 (3-7) in the overall cohort and 6 (4-8) among patients with a final outcome). For the patients with a final outcome (477/883, 54.0%) the median (IQR) number of months of anti-TB treatment was 18 (13-23) (in days 553 (385-678)). The proportion of patients achieving sputum smear and culture conversion ranged from 93.4% and 92.8% respectively (whole cohort) to 89.3% and 88.8% respectively (patients with a final outcome), a median (IQR) time to sputum smear and culture conversion of 58 (30-90) days for the whole cohort and 60 (30-100) for patients with a final outcome and, respectively, of 55 (30-90) and 60 (30-90) days for culture conversion. Of 383 patients treated with bedaquiline but not delamanid, 284 (74.2%) achieved treatment success, while 25 (6.5%) died, 11 (2.9%) failed and 63 (16.5%) were lost to follow-up. (C) 2021 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L.U.

引用

页码：403 / 412

页数：10

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← 1 2 3 4 5 →

共 49 条

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Ahmad, Nafees ;

Ahuja, Shama D. ;

Akkerman, Onno W. ;

Alffenaar, Jan-Willem C. ;

Anderson, Laura F. ;

Baghaei, Parvaneh ;

Bang, Didi ;

Barry, Pennan M. ;

Bastos, Mayara L. ;

Behera, Digamber ;

Benedetti, Andrea ;

Bisson, Gregory P. ;

Boeree, Martin J. ;

Bonnet, Maryline ;

Brode, Sarah K. ;

Brust, James C. M. ;

Cai, Ying ;

Caumes, Eric ;

Cegielski, J. Peter ;

Centis, Rosella ;

Chan, Pei-Chun ;

Chan, Edward D. ;

Chang, Kwok-Chiu ;

Charles, Macarthur ;

Cirule, Andra ;

Dalcolmo, Margareth Pretti ;

D'Ambrosio, Lia ;

de Vries, Gerard ;

Dheda, Keertan ;

Esmail, Aliasgar ;

Flood, Jennifer ;

Fox, Gregory J. ;

Frechet-Jachym, Mathilde ;

Fregona, Geisa ;

Gayoso, Regina ;

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Gu, Sue ;

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Holtz, Timothy H. ;

Hughes, Jennifer ;

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Kempker, Russell R. ;

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D'Ambrosio, Lia ;

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Elamin, Seifeldin Eltaeb ;

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Ganatra, Shashank ;

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Garcia-Garcia, Jose-Maria ;

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Hoefsloot, Wouter ;

Ilievska-Poposka, Biljana ;

Jonsson, Jerker ;

Khimova, Elena ;

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Kunst, Heinke ;

Laniado-Laborin, Rafael ;

Li, Yang ;

Magis-Escurra, Cecile ;

Manfrin, Vinicio ;

Manga, Selene ;

Marchese, Valentina ;

Martinez Robles, Elena ;

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Akkerman, Onno W. ;

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Maeurer, Markus ;

Visca, Dina ;

Munoz-Torrico, Marcela ;

Tiberi, Simon ;

Migliori, Giovanni Battista .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 92 :S10-S14

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Avaliani, Zaza ;

Gozalov, Ogtay ;

Kuchukhidze, Giorgi ;

Skrahina, Alena ;

Soltan, Viorel ;

van den Boom, Martin ;

Vasilyeva, Irina ;

Vilc, Valentina ;

Yedilbayev, Askar .

EUROPEAN RESPIRATORY JOURNAL, 2020, 56 (01)

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INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2020, 24 (10) :1058-+

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Borisov, Sergey ;

Danila, Edvardas ;

Maryandyshev, Andrei ;

Dalcolmo, Margareth ;

Miliauskas, Skaidrius ;

Kuksa, Liga ;

Manga, Selene ;

Skrahina, Alena ;

Diktanas, Saulius ;

Codecasa, Luigi Ruffo ;

Aleksa, Alena ;

Bruchfeld, Judith ;

Koleva, Antoniya ;

Piubello, Alberto ;

Udwadia, Zarir Farokh ;

Akkerman, Onno W. ;

Belilovski, Evgeny ;

Bernal, Enrique ;

Boeree, Martin J. ;

Cadinanos Loidi, Julen ;

Cai, Qingshan ;

Cebrian Gallardo, Jose Joaquin ;

Dara, Masoud ;

Davidaviciene, Edita ;

Forsman, Lina Davies ;

De Los Rios, Jorge ;

Denholm, Justin ;

Draksiene, Jacinta ;

Duarte, Raquel ;

Elamin, Seifeldin Eltaeb ;

Escobar Salinas, Nadia ;

Ferrarese, Maurizio ;

Filippov, Alexey ;

Garcia, Ana ;

Garcia-Garcia, Jose-Maria ;

Gaudiesiute, Ieva ;

Gavazova, Blagovesta ;

Gayoso, Regina ;

Rosso, Roscio Gomez ;

Gruslys, Vygantas ;

Gualano, Gina ;

Hoefsloot, Wouter ;

Jonsson, Jerker ;

Khimova, Elena ;

Kunst, Heinke ;

Laniado-Laborin, Rafael ;

Li, Yang ;

Magis-Escurra, Cecile ;

Manfrin, Vinicio ;

Marchese, Valentina .

EUROPEAN RESPIRATORY JOURNAL, 2019, 54 (06)

[7] Outcomes of patients with drug-resistant-tuberculosis treated with bedaquiline-containing regimens and undergoing adjunctive surgery [J].

Borisov, Sergey E. ;

D'Ambrosio, Lia ;

Centis, Rosella ;

Tiberi, Simon ;

Dheda, Keertan ;

Alffenaar, Jan-Willem ;

Amale, Rohit ;

Belilowski, Evgeny ;

Bruchfeld, Judith ;

Canneto, Barbara ;

Denholm, Justin ;

Duarte, Raquel ;

Esmail, Aliasgar ;

Filippov, Alex ;

Forsman, Lina Davies ;

Gaga, Mina ;

Ganatra, Shashank ;

Igorevna, Gaida Anastasia ;

Mastrapa, Barbara Lazaro ;

Manfrin, Vinicio ;

Manga, Selene ;

Maryandyshev, Andrey ;

Massard, Gilbert ;

Gonzalez Montaner, Pablo ;

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