Determining the Minimal Clinically Important Difference and Responsiveness of the Dermatogy Life Quality Index (DLQI): Further Data

被引：346

作者：

Basra, M. K. A. ^{[1
]}

Salek, M. S. ^{[2
,3
]}

Camilleri, L. ^{[4
]}

Sturkey, R. ^{[4
]}

Finlay, A. Y. ^{[5
]}

机构：

[1] Derriford Hosp, Dept Dermatol, Plymouth PL6 8DH, Devon, England

[2] Univ Hertfordshire, Dept Pharm, Hatfield AL10 9AB, Herts, England

[3] Inst Med Dev, Cardiff, S Glam, Wales

[4] Cardiff Univ, Sch Pharm & Pharmaceut Sci, Ctr Socioecon Res, Cardiff CF10 3AX, S Glam, Wales

[5] Cardiff Univ, Sch Med, Dept Dermatol & Wound Healing, Cardiff CF10 3AX, S Glam, Wales

来源：

DERMATOLOGY | 2015年 / 230卷 / 01期

关键词：

DLQI; MCID; Responsiveness; Minimum clinically important difference; Skin disease; OF-LIFE; PSORIASIS PATIENTS; BACK-PAIN; INSTRUMENTS; QUESTIONNAIRE; SEVERITY; OUTCOMES; DISEASE;

D O I：

10.1159/000365390

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Aims: To determine the minimal clinically important difference (MCID) of the Dermatology Life Quality Index (DLQI) and its responsiveness to change in inflammatory skin diseases. Methods: A longitudinal study: at stage 1, patients completed the DLQI and a disease severity global question; at stage 2, a global rating of change in quality of life (QoL; Global Rating of Change Questionnaire, GRCQ) was added and used as an anchor to measure the MCID of the DLQI. Results: 192 patients completed stage 1 and 107 completed stage 2. The mean DLQI score at stage 1 was 9.8 and 7.4 at stage 2 with a mean change of 2.4 (p <0.0001). 31 patients experienced a 'small change' in their QoL (+/- 3 and +/- 2) on the GRCQ. The mean corresponding change in DLQI scores was 3.3, which is regarded as the approximate MCID. Conclusions: Previous estimates of the MCID of the DLQI have varied from 3 to 5. Although this study demonstrated a MCID of 3.3, we recommend that the MCID in inflammatory skin diseases should be 4. (C) 2015 S. Karger AG, Basel

引用

页码：27 / 33

页数：7

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