Balanced propofol sedation for therapeutic GI endoscopic procedures: a prospective, randomized study

被引：59

作者：

Lee, Chang Kyun ^{[1
]}

Lee, Suck-Ho ^{[2
]}

Chung, Il-Kwun ^{[2
]}

Lee, Tae Hoon ^{[2
]}

Park, Sang-Heum ^{[2
]}

Kim, Eun-Ok ^{[2
]}

Lee, Sae Hwan ^{[2
]}

Kim, Hong-Soo ^{[2
]}

Kim, Sun-Joo ^{[2
]}

机构：

[1] Kyung Hee Univ, Sch Med, Div Gastroenterol, Dept Internal Med, Seoul 130702, South Korea

[2] Soon Chun Hyang Univ Coll Med, Cheonan Hosp, Dept Internal Med, Div Gastroenterol, Cheonan, South Korea

来源：

GASTROINTESTINAL ENDOSCOPY | 2011年 / 73卷 / 02期

关键词：

GASTROENTEROLOGIST-ADMINISTERED PROPOFOL; HIGH-RISK OCTOGENARIANS; LOW-DOSE PROPOFOL; GASTROINTESTINAL ENDOSCOPY; DEEP SEDATION; INTRAVENOUS PROPOFOL; MONITORING PRACTICE; MODERATE SEDATION; NATIONWIDE SURVEY; ROUTINE ERCP;

D O I：

10.1016/j.gie.2010.09.035

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: There are few controlled studies on balanced propofol sedation (BPS) for therapeutic endoscopy. Objective: To compare the safety and efficacy of BPS (propofol in combination with midazolam and meperidine) with conventional sedation (midazolam and meperidine) in patients undergoing therapeutic endoscopic procedures. Design: Prospective, randomized, single-blinded study. Setting: Tertiary-care referral center. Patients: This study involved 222 consecutive patients undergoing therapeutic EGD or ERCP from July 2009 to March 2010. Intervention: Conventional sedation or BPS by trained registered nurses under endoscopist supervision. Main Outcome Measurements: Rates of sedation-related cardiopulmonary complications and interruption of the procedures, procedure-related times, and assessments of health care providers (endoscopists and sedation nurses) and patients. Results: There were no significant differences between the BPS and conventional groups in the rates of cardiopulmonary complications (8.8% [9/102] vs 5.8% [6/104], respectively) and transient interruption of procedures (2.9% [3/102] vs 0% [0/104], respectively). No patient required assisted ventilation or premature termination of a procedure. BPS provided significantly higher health care provider satisfaction (mean +/- SD 10-cm visual analog scale [VAS] score) compared with conventional sedation (endoscopists: 7.57 +/- 2.61 vs 6.55 +/- 2.99, respectively; P = .011; sedation nurses: 7.86 +/- 2.31 vs 6.67 +/- 2.90, respectively; P = .001). Patient cooperation was significantly better in the BPS group (VAS; endoscopists: 7.24 +/- 2.97 vs 6.27 +/- 3.09, P = .024; sedation nurses: 7.75 +/- 2.30 vs 6.54 +/- 2.99, P = .001). Limitations: Single-center and single-blinded study. Conclusion: Compared with conventional sedation. BPS provides higher health care provider satisfaction, better patient cooperation, and similar adverse event profiles in patients undergoing therapeutic endoscopic procedures. (Gastrointest Endosc 2011;73:206-14.)

引用

页码：206 / 214

页数：9

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