Aptamer-Mediated Up-conversion Core/MOF Shell Nanocomposites for Targeted Drug Delivery and Cell Imaging

被引：184

作者：

Deng, Kerong ^{[1
,2
]}

Hou, Zhiyao ^{[1
]}

Li, Xuejiao ^{[1
]}

Li, Chunxia ^{[1
]}

Zhang, Yuanxin ^{[1
]}

Deng, Xiaoran ^{[1
,2
]}

Cheng, Ziyong ^{[1
]}

Lin, Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

中国国家自然科学基金;

关键词：

METAL-ORGANIC FRAMEWORKS; NANOPARTICLES; NANOMATERIALS; CHALLENGES; PROBES;

D O I：

10.1038/srep07851

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Multifunctional nanocarriers for targeted bioimaging and drug delivery have attracted much attention in early diagnosis and therapy of cancer. In this work, we develop a novel aptamer-guided nanocarrier based on the mesoporous metal-organic framework (MOF) shell and up-conversion luminescent NaYF4:Yb3+/Er3+ nanoparticles (UCNPs) core for the first time to achieve these goals. These UCNPs, chosen as optical labels in biological assays and medical imaging, could emit strong green emission under 980 nm laser. The MOF structure based on iron (III) carboxylate materials [MIL-100 (Fe)] possesses high porosity and non-toxicity, which is of great value as nanocarriers for drug storage/delivery. As a unique nanoplatform, the hybrid inorganic-organic drug delivery vehicles show great promising for simultaneous targeted labeling and therapy of cancer cells.

引用

页数：7

共 33 条

[1] In depth analysis of the in vivo toxicity of nanoparticles of porous iron(III) metal-organic frameworks [J].

Baati, Tarek ;

Njim, Leila ;

Neffati, Fadoua ;

Kerkeni, Abdelhamid ;

Bouttemi, Muriel ;

Gref, Ruxandra ;

Najjar, Mohamed Fadhel ;

Zakhama, Abdelfateh ;

Couvreur, Patrick ;

Serre, Christian ;

Horcajada, Patricia .

CHEMICAL SCIENCE, 2013, 4 (04) :1597-1607

[2] Understanding the Colloidal Stability of the Mesoporous MIL-100(Fe) Nanoparticles in Physiological Media [J].

Bellido, Elena ;

Guillevic, Mazheva ;

Hidalgo, Tania ;

Santander-Ortega, Manuel J. ;

Serre, Christian ;

Horcajada, Patricia .

LANGMUIR, 2014, 30 (20) :5911-5920

[3]

Chalati T, 2011, NANOMEDICINE-UK, V6, P1683, DOI [10.2217/NNM.11.69, 10.2217/nnm.11.69]

[4] One-Step Facile Surface Engineering of Hydrophobic Nanocrystals with Designer Molecular Recognition [J].

Chen, Tao ;

Oecsoy, Ismail ;

Yuan, Quan ;

Wang, Ruowen ;

You, Mingxu ;

Zhao, Zilong ;

Song, Erqun ;

Zhang, Xiaobing ;

Tan, Weihong .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (32) :13164-13167

[5] Multifunctional nanoparticles for upconversion luminescence/MR multimodal imaging and magnetically targeted photothermal therapy [J].

Cheng, Liang ;

Yang, Kai ;

Li, Yonggang ;

Zeng, Xiao ;

Shao, Mingwang ;

Lee, Shuit-Tong ;

Liu, Zhuang .

BIOMATERIALS, 2012, 33 (07) :2215-2222

[6] Facile Preparation of Multifunctional Upconversion Nanoprobes for Multimodal Imaging and Dual-Targeted Photothermal Therapy [J].

Cheng, Liang ;

Yang, Kai ;

Li, Yonggang ;

Chen, Jianhua ;

Wang, Chao ;

Shao, Mingwang ;

Lee, Shuit-Tong ;

Liu, Zhuang .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (32) :7385-7390

[7] Rationale of Drug Encapsulation and Release from Biocompatible Porous Metal-Organic Frameworks [J].

Cunha, Denise ;

Ben Yahia, Mouna ;

Hall, Shaun ;

Miller, Stuart R. ;

Chevreau, Hubert ;

Elkaim, Erik ;

Maurin, Guillaume ;

Horcajada, Patricia ;

Serre, Christian .

CHEMISTRY OF MATERIALS, 2013, 25 (14) :2767-2776

[8] In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles [J].

Dai, Yunlu ;

Xiao, Haihua ;

Liu, Jianhua ;

Yuan, Qinghai ;

Ma, Ping'an ;

Yang, Dongmei ;

Li, Chunxia ;

Cheng, Ziyong ;

Hou, Zhiyao ;

Yang, Piaoping ;

Lin, Jun .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (50) :18920-18929

[9] Nanoscale Metal-Organic Frameworks for Biomedical Imaging and Drug Delivery [J].

Della Rocca, Joseph ;

Liu, Demin ;

Lin, Wenbin .

ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :957-968

[10] Upconversion-Nanophosphor-Based Functional Nanocomposites [J].

Feng, Wei ;

Han, Chunmiao ;

Li, Fuyou .

ADVANCED MATERIALS, 2013, 25 (37) :5287-5303

← 1 2 3 4 →