Effect of Calcium Dobesilate in Preventing Contrast-Induced Nephropathy in Patients with Diabetes and Chronic Kidney Disease

被引：3

作者：

Zhang, Hao ^{[1
]}

Guo, Shao-Hua ^{[1
]}

Xue, Zheng-Kai ^{[1
]}

Zhang, Ya-Ru ^{[1
]}

Wang, Jia-Rui ^{[1
]}

Che, Jing-Jin ^{[1
]}

Liu, Tong ^{[1
]}

Tao, Hua-Yue ^{[2
]}

Li, Guang-Ping ^{[1
]}

Rha, Seung-Woon ^{[3
]}

Ashraful-Haque, Swapnil-Zaman ^{[1
]}

Chen, Kang-Yin ^{[1
]}

机构：

[1] Tianjin Med Univ, Tianjin Inst Cardiol, Dept Cardiol, Hosp 2,Tianjin Key Lab Ion Mol Funct Cardiovasc D, Tianjin 300211, Peoples R China

[2] Tianjin Med Univ, Informat Dept, Hosp 2, Tianjin 300211, Peoples R China

[3] Korea Univ, Cardiac Ctr, Guro Hosp, Seoul 152703, South Korea

来源：

CLINICS | 2021年 / 76卷

关键词：

Calcium dobesilate; Contrast-Induced Acute Kidney Injury; Diabetes Mellitus; Chronic Renal Insufficiency; Coronary Angiography; PERCUTANEOUS CORONARY INTERVENTION; RENAL-FAILURE; RISK-FACTORS; CYSTATIN C; INJURY; ANGIOGRAPHY; BIOMARKERS; MELLITUS;

D O I：

10.6061/clinics/2021/e2942

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES: This study assessed the protective effect of calcium dobesilate against contrast-induced nephropathy (CIN) after coronary angiography (CAG) or percutaneous coronary intervention (PCI) in patients with diabetes and chronic kidney disease (CKD). METHODS: A total of 130 patients with diabetes and CKD estimated glomerular filtration rate: 30-90 mL/min/1.73m(2) were enrolled and included in the analysis. They were divided into experimental (n=65) and control groups (n=65). Patients in the experimental group were administered oral calcium dobesilate (500 mg) three times daily for 2 days before and 3 days after the procedure. The serum creatinine (SCr), cystatin C (Cys C), and neutrophil gelatinase-associated lipocalin (NGAL) levels were measured before and after the procedure. RESULTS: The mean SCr level at 24h after the procedure was found to be significantly lower in the experimental group than in the control group (79.1 +/- 19.6 mmol/L vs. 87.0 +/- 19.3 mmol/L, p=0.023). However, the Cys C and NGAL levels were not significantly different between the two groups at all measurement time points (all p>0.05). The incidence of CIN defined by the SCr level was significantly lower in the experimental group than in the control group (3 [4.6%] vs. 13 [20.0%], p=0.017). However, the incidence of CIN defined by the Cys C level was not statistically different between the two groups (7 [10.8%] vs. 7 [10.8%], p=1.000). CONCLUSIONS: This study revealed that calcium dobesilate has no preventive effect against CIN in patients with diabetes and CKD.

引用

页数：9

共 38 条

[1] Serum Neutrophil Gelatinase-Associated Lipocalin and Cystatin C are early Biomarkers of Contrast-Induced Nephropathy After Coronary Angiography in Patients With Chronic Kidney Disease [J].