Central Role of Transforming Growth Factor Type Beta 1 in Skeletal Muscle Dysfunctions: An Update on Therapeutic Strategies

被引：19
作者：
Abrigo, Johanna [1 ,2 ,3 ]
Simon, Felipe [2 ,3 ,4 ]
Cabrera, Daniel [5 ,6 ]
Cordova, Gonzalo [7 ]
Trollet, Capucine [7 ]
Cabello-Verrugio, Claudio [1 ,2 ,3 ]
机构：
[1] Univ Andres Bello, Lab Muscle Pathol Fragil & Aging, Dept Ciencias Biol, Fac Ciencias Biol, Av Republ 239 Piso 2, Santiago 8370146, Chile
[2] Univ Andres Bello, Fac Med, Av Republ 239 Piso 2, Santiago 8370146, Chile
[3] Millennium Inst Immunol & Immunotherapy, Santiago, Chile
[4] Univ Andres Bello, Lab Integrat Physiopathol, Dept Ciencias Biol, Fac Ciencias Biol, Santiago, Chile
[5] Pontificia Univ Catolica Chile, Fac Med, Dept Gastroenterol, Santiago, Chile
[6] Univ Bernardo O Higgins, Fac Salud, Dept Ciencias Quim & Biol, Santiago, Chile
[7] UPMC Univ Paris 6, Sorbonne Univ, Inst Myol, INSERM,UM76,U974, 47 Bd Hop, F-75013 Paris, France
来源：
CURRENT PROTEIN & PEPTIDE SCIENCE | 2018年 / 19卷 / 12期
关键词：
Muscle atrophy; fibrosis; dystrophy; renin angiotensin system; blocking antibodies; therapy; TGF-BETA; ANGIOTENSIN-II; MUSCULAR-DYSTROPHY; MDX MOUSE; TRANSCRIPTION FACTORS; COLLAGEN-SYNTHESIS; FIBROSIS; DIFFERENTIATION; RECEPTOR; CELL;
D O I：
10.2174/1389203718666171117101916
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-beta 1) is one of the most studied. This factor inhibits myogenesis and regeneration by regulating the activity and function of satellite cells (SCs). Indeed, TGF-beta has a central role in muscle pathologies in which there is development of fibrosis and/or atrophy of skeletal muscle. Thus, in this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-beta 1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-beta in skeletal muscle is discussed.
引用
收藏
页码：1189 / 1200
页数：12
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