Association between vitamin D receptor Fokl polymorphism and serum parathyroid hormone level in patients with chronic renal failure

被引:28
作者
Gago, EV
Cadarso-Suárez, C
Perez-Fernandez, R
Burgos, RR
Mugica, JD
Iglesias, CS [1 ]
机构
[1] Univ Santiago de Compostela, Sch Med, Dept Morphol Sci, Santiago De Compostela 15782, Spain
[2] Univ Santiago de Compostela, Sch Med, Dept Physiol, Santiago De Compostela 15782, Spain
[3] Univ Santiago de Compostela, Sch Med, Dept Stat & Operat Res, Santiago De Compostela 15782, Spain
[4] Univ Santiago de Compostela, Sch Med, Dept Nephrol, Santiago De Compostela 15782, Spain
关键词
Fokl polymorphism; parathyroid hormone; hyperparathyroidism; population study; VDR polymorphism; vitamin D receptor;
D O I
10.1007/BF03345353
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We investigated the relationship between vitamin D receptor (VDR) start codon polymorphism and serum levels of PTH, calcidiol, and calcium in 64 Spanish patients with chronic renal failure (CRF). An exon 2 fragment of the VDR gene was amplified by PCR, and cleaved with the restriction enzyme Fokl. The alleles were identified according to the digestion pattern obtained as F (absence of restriction site) and f (presence of restriction site). Genotype frequencies in the patient population were 54.7% FF, 28.1% Ff and 17.2% ff, vs 46.7% FF, 43.3% Ff and 10% ff in a healthy control population. The difference between the two populations was statistically significant (p < 0.01). Within the patient population, mean serum PTH level in the FF group was significantly higher (159.77 +/- 25.69 pg/ml) than in both the Ff and ff groups (106.67 +/- 19.07 and 77.55 +/- 15.85 pg/ml, respectively; p < 0.05). However there were no significant differences in serum levels of calcidiol or calcium among genotypes. These results suggest that Fokl polymorphisms of the VDR gene may determine parathyroid response in CRF patients. (c) 2005, Editrice Kurtis.
引用
收藏
页码:117 / 121
页数:5
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