GSK-3 mediates NO-cGMP-induced isoflavone production in soybean sprouts

被引：9
作者：
Jiao, Caifeng [1 ]
Zhu, Liangliang [1 ]
Gu, Zhenxin [2 ]
机构：
[1] Anqing Normal Univ, Coll Life Sci, Anqing 246133, Anhui, Peoples R China
[2] Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China
来源：
FOOD RESEARCH INTERNATIONAL | 2017年 / 101卷
基金：
中国国家自然科学基金;
关键词：
GSK-3; NO-cGMP; UV-B; Isoflavone; Soybean sprouts; DEPENDENT PROTEIN-KINASE; UV-B IRRADIATION; GENE-EXPRESSION; CELL-CULTURES; ABSCISIC-ACID; SMOOTH-MUSCLE; SYNTHASE; ACTIVATION; PHOSPHORYLATION; ACCUMULATION;
D O I：
10.1016/j.foodres.2017.09.002
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The role of glycogen synthase kinase-3 (GSK-3) in the nitric oxide-guanosine 3',5'-cyclic monophosphate (NO-cGMP)-induced isoflavone production in soybean sprouts was examined. Inhibitors and donors of NO, cGMP, and GSK-3 inhibitor were added to UV-B irradiated sprouts. Results showed that NO, with cGMP, induced the expression of GSK-3 under UV-B radiation. Protein kinase G (PKG) was shown to be involved in NO-cGMP-induced GSK-3 activation. GSK-3 elevated activity and expression levels of chalcone synthase (CHS) and isoflavone synthase (IFS), and increased isoflavone accumulation.
引用
收藏
页码：203 / 208
页数：6
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