Self-renewal capacity of human epidermal Langerhans cells: observations made on a composite tissue allograft

被引：74

作者：

Kanitakis, Jean ^{[1
,2
]}

Morelon, Emmanuel ^{[3
]}

Petruzzo, Palmina ^{[4
]}

Badet, Lionel ^{[4
]}

Dubernard, Jean-Michel ^{[4
]}

机构：

[1] Univ Lyon 1, Dept Dermatol Pav R, Ed Herriot Hosp, F-69437 Lyon 03, France

[2] Univ Lyon 1, Dermatopathol Lab, Ed Herriot Hosp, F-69437 Lyon 03, France

[3] Univ Lyon 1, Dept Transplantat Immunol Pav P, Ed Herriot Hosp, F-69437 Lyon 03, France

[4] Ed Herriot Hosp, Dept Transplantat Surg Pav V, Lyon 03, France

来源：

EXPERIMENTAL DERMATOLOGY | 2011年 / 20卷 / 02期

关键词：

MONOCLONAL-ANTIBODY RITUXIMAB; PEMPHIGUS-VULGARIS ANTIGEN; HUMORAL IMMUNE-RESPONSE; PATHOGENIC AUTOANTIBODIES; KERATINOCYTE ADHESION; GEL; 4-PERCENT; DESMOGLEIN-3; RECEPTORS; DOMAIN; MODEL;

D O I：

10.1111/j.1600-0625.2010.01146.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Epidermal Langerhans cells (LC) are dendritic, antigen-presenting cells residing within mammalian epidermis and mucosal epithelia. When massively depleted, they are replaced by cells of bone-marrow origin. However, their renewal within normal skin under steady-state conditions is not precisely known. We observed that epidermal LC within a human hand allograft remain stable in the long term (10 years) and are not replaced by cells of recipient's origin; furthermore, we observed a Langerhans cell in mitosis within the epidermis 8 years postgraft. These results show that under almost physiological conditions, human LC renew in the epidermis by local mitoses of preexisting cells.

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页码：145 / 146

页数：2

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