A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

被引：352

作者：

Roberts, Megan N. ^{[1
]}

Wallace, Marita A. ^{[2
]}

Tomilov, Alexey A. ^{[1
]}

Zhou, Zeyu ^{[1
]}

Marcotte, George R. ^{[2
]}

Tran, Dianna ^{[1
]}

Perez, Gabriella ^{[1
]}

Gutierrez-Casado, Elena ^{[7
]}

Koike, Shinichiro ^{[3
]}

Knotts, Trina A. ^{[1
]}

Imai, Denise M. ^{[4
]}

Griffey, Stephen M. ^{[4
]}

Kim, Kyoungmi ^{[5
]}

Hagopian, Kevork ^{[1
]}

Haj, Fawaz G. ^{[3
]}

Baar, Keith ^{[2
,6
]}

Cortopassi, Gino A. ^{[1
]}

Ramsey, Jon J. ^{[1
]}

Alberto Lopez-Dominguez, Jose ^{[1
,8
]}

机构：

[1] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA

[2] Univ Calif Davis, Dept Neurobiol Physiol & Behav, Sch Vet Med, Davis, CA 95616 USA

[3] Univ Calif Davis, Dept Nutr, Sch Vet Med, Davis, CA 95616 USA

[4] Univ Calif Davis, Comparat Pathol Lab, Sch Vet Med, Davis, CA 95616 USA

[5] Univ Calif Davis, Sch Med, Dept Publ Hlth Sci, Davis, CA 95616 USA

[6] Univ Calif Davis, Sch Med, Dept Physiol & Membrane Biol, Davis, CA 95616 USA

[7] Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba, Spain

[8] Buck Inst Res Aging, Novato, CA 94945 USA

来源：

CELL METABOLISM | 2017年 / 26卷 / 03期

关键词：

CALORIE RESTRICTION; LIFE-SPAN; PROTEIN-INTAKE; C57BL/6J MICE; METHIONINE; RAT; REGENERATION; METABOLITES; RESISTANCE; STRESS;

D O I：

10.1016/j.cmet.2017.08.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12 months of age and were either allowed to live their natural lifespan or tested for physiological function after 1 or 14 months of dietary intervention. The ketogenic diet (KD) significantly increased median lifespan and survival compared to controls. In aged mice, only those consuming a KD displayed preservation of physiological function. The KD increased protein acetylation levels and regulated mTORC1 signaling in a tissue-dependent manner. This study demonstrates that a KD extends longevity and healthspan in mice.

引用

页码：539 / +

页数：13

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