Vitamin E in uremia and dialysis patients

被引：19

作者：

Galli, F ^{[1
]}

Buoncristiani, U ^{[1
]}

Conte, C ^{[1
]}

Aisa, C ^{[1
]}

Floridi, A ^{[1
]}

机构：

[1] Univ Perugia, Dept Internal Med, Sect Appl Biochem & Nutr Sci, I-06126 Perugia, Italy

来源：

VITAMIN E AND HEALTH | 2004年 / 1031卷

关键词：

vitamin E; tocopherol; CEHCs; uremia; hemodialysis; end-stage renal disease; oxidative stress; lipid oxidation; antioxidants;

D O I：

10.1196/annals.1331.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vitamin E therapy (based either on oral supplements or new dialysis methods such as vitamin E-coated hemodialysers) has been suggested to yield a better clinical outcome in hemodialysis (HD) patients than in other populations of patients. Among other factors, the presence of a modified vitamin E status might help to explain this apparently paradoxical response to vitamin E. In this study we investigated 104 regular HD patients. The results indicate that, besides having a low dietary intake, these subjects show some abnormalities in the levels and metabolism of vitamin E, such as a disproportion between plasma tocopherols and lipids, low levels of gamma-T, and CEHC accumulation. Although further studies are needed to confirm the clinical relevance of vitamin E therapy in HD, these findings might lead to recommending a higher vitamin E intake in these patients.

引用

页码：348 / 351

页数：4

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