Insulin resistance in adolescents

被引：20

作者：

Rodden, Ann M. ^{[1
]}

Diaz, Vanessa A. ^{[1
]}

Mainous, Arch G., III ^{[1
]}

Koopman, Richellf J. ^{[1
]}

Geesey, Mark E. ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Family Med, Charleston, SC 29425 USA

来源：

JOURNAL OF PEDIATRICS | 2007年 / 151卷 / 03期

关键词：

D O I：

10.1016/j.jpeds.2007.03.023

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objectives To investigate the relationship of other body mass index (BMI) ranges with Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), a surrogate marker for insulin resistance in adolescents. Study design Cross-sectional analysis of a nationally representative sample of 1837 nondiabetic, nonpregnant 12 to 19 year old persons from the National Health and Nutrition Examination Survey, 1999-2002. The main outcome measurement of insulin resistance was calculated as HOMA-IR > 3.16. Results Having aBMI >= 75(th) percentile is associated with a high HOMA-IR levels. As the BMI percentile increases, the odds of high HOMA-IR levels increase (BMI percentile 75-84.9, OR 4.277, 95% CI 2.090-8.752; BMI percentile 85-94.9, OR 4.299, 95% CI 2.158-8.563; BMI >= 95(th)) percentile, OR 17.907, 95% CI 11.360-28.228). Conclusion Adolescents with BMI percentile of 75 to 84.9, which represents approximately 1.2 million US adolescents, have not previously been identified as having higher HOMA-IR levels.

引用

页码：275 / 279

页数：5

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