The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes

被引：150

作者：

Rantakari, Pia ^{[1
]}

Auvinen, Kaisa ^{[1
]}

Jappinen, Norma ^{[1
]}

Kapraali, Maria ^{[1
]}

Valtonen, Joona ^{[1
]}

Karikoski, Marika ^{[1
]}

Gerke, Heidi

Iftakhar-E-Khuda, Imtiaz ^{[1
]}

Keuschnigg, Johannes ^{[1
]}

Umemoto, Eiji ^{[2
]}

Tohya, Kazuo ^{[3
]}

Miyasaka, Masayuki ^{[1
,2
]}

Elima, Kati ^{[1
,4
]}

Jalkanen, Sirpa ^{[1
,5
]}

Salmi, Marko ^{[1
,5
]}

机构：

[1] Univ Turku, MediCity Res Lab, Turku, Finland

[2] Osaka Univ, WPI Immunol Frontier Res Ctr, Suita, Osaka 565, Japan

[3] Kansai Univ Hlth Sci, Dept Anat, Osaka, Japan

[4] Univ Turku, Dept Med Biochem & Genet, Turku, Finland

[5] Univ Turku, Dept Med Microbiol & Immunol, Turku, Finland

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 04期

关键词：

FENESTRAL DIAPHRAGMS; DENDRITIC CELLS; AFFERENT LYMPH; T-CELLS; BLOOD; DIFFERENTIATION; DIAPEDESIS; MECHANISM; MIGRATION; TRANSPORT;

D O I：

10.1038/ni.3101

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the lymphatic sinuses of draining lymph nodes, soluble lymph-borne antigens enter the reticular conduits in a size-selective manner and lymphocytes transmigrate to the parenchyma. The molecular mechanisms that control these processes are unknown. Here we unexpectedly found that PLVAP, a prototypic endothelial protein of blood vessels, was synthesized in the sinus-lining lymphatic endothelial cells covering the distal conduits. In PLVAP-deficient mice, both small antigens and large antigens entered the conduit system, and the transmigration of lymphocytes through the sinus floor was augmented. Mechanistically, the filtering function of the lymphatic sinus endothelium was dependent on diaphragms formed by PLVAP fibrils in transendothelial channels. Thus, in the lymphatic sinus, PLVAP forms a physical sieve that regulates the parenchymal entry of lymphocytes and soluble antigens.

引用

页码：386 / 396

页数：11

共 43 条

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