Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation

被引：89

作者：

Awale, S

Nakashima, EMN

Kalauni, SK

Tezuka, Y

Kurashima, Y

Lu, J

Esumi, H

Kadota, S

机构：

[1] Toyama Med & Pharmaceut Univ, Inst Nat Med, Toyama 9300194, Japan

[2] Natl Canc Ctr, Res Inst E, Investigat Treatment Div, Chiba 2778577, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 03期

关键词：

PANC-1; anti-austerity; screening strategy; angelmarin; angelica pubescens; anti-cancer agent;

D O I：

10.1016/j.bmcl.2005.10.046

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The CH2Cl2-soluble extract of Angelica pubescens was found to kill PANC-1 cancer cells preferentially under nutrition starvation at a concentration of 50 mu g/ml, with virtually no cytotoxicity under nutrient-rich conditions. Further bioassay-guided fractionation and isolation led to the isolation of a novel compound named angelmarin as the primary compound responsible for the preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against PANC-1 cells at a concentration of 0.01 mu g/ml. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：581 / 583

页数：3

共 12 条

[1] A prospective randomized study of gemcitabine with doxifluridine versus paclitaxel with doxifluridine in concurrent chemoradiotherapy for locally advanced pancreatic cancer [J].