Ruthenium (III) Chloride complex with Salicylaldehyde: Synthesis, characterization and interaction with albumin and DNA

Reaction between RuCl3 and salicyladehyde was performed in the presence of triethylamine in acetone solution. On the basis of analytical data, IR, UV-Vis spectroscopy and cyclic voltammetry, an empirical formula for the acetone solvate [RuCl(2)Sal] x 0.6 x Et3NHCl Me2CO can be attributed to the product. The carbonyl and phenol groups from salicylaldehyde showed shifts towards lower and higher frequencies respectively after the coordination, which is in accordance with an anionic binding mode of ligand. Hydrolysis in the presence of bovine serum albumin resulted in the appearance of new absorption bands centered at 420 nm indicating an interactions of Ru(III) compound with albumin. The decreasing of the absorption of complex at 260 nm due to hydrolysis in the presence of DNA was slower which indicates a possible interaction.