Deficient regulatory B cells in human chronic graft-versus-host disease

被引：15

作者：

de Masson, Adele ^{[1
,2
]}

Socie, Gerard ^{[3
]}

Bagot, Martine ^{[1
,2
]}

Bensussan, Armand ^{[2
]}

Bouaziz, Jean-David ^{[1
,2
]}

机构：

[1] Hop St Louis, Serv Dermatol, F-75475 Paris, France

[2] Univ Paris 07, Hop St Louis, Sorbonne Paris Cite,INSERM,UMRS 976, Lab Oncodermatol Immunol & Cutaneous Stem Cells, Paris, France

[3] Univ Paris 07, Hop St Louis, Sorbonne Paris Cite, Serv Hematol Greffes,INSERM,UMRS 1160, Paris, France

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 07期

关键词：

chronic graft-versus-host disease; allogeneic stem cell transplantation; regulatory B cells; interleukin-10; SUBSET; IL-10;

D O I：

10.1080/2162402X.2015.1016707

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human chronic graft-versus-host disease (cGVHD) is a frequent and disabling complication of allogeneic hematopoietic stem cell transplantation. Regulatory B cells (Bregs) are IL-10-producing B cells that are able to inhibit the innate and adaptive immune responses. We have recently demonstrated a defect in regulatory B cells in human cGVHD.

引用

页码：1 / 3

页数：3

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