Evaluation of Transplacental Antibody Transfer in SARS-CoV-2-Immunized Pregnant Women

被引:27
作者
Shen, Ching-Ju [1 ]
Fu, Yi-Chen [2 ]
Lin, Yen-Pin [2 ]
Shen, Ching-Fen [3 ]
Sun, Der-Ji [4 ]
Chen, Huan-Yun [5 ]
Cheng, Chao-Min [2 ]
机构
[1] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Obstet & Gynecol, Kaohsiung 807, Taiwan
[2] Natl Tsing Hua Univ, Inst Biomed Engn, Hsinchu 300, Taiwan
[3] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Pediat, Coll Med, Tainan 704, Taiwan
[4] Pojen Hosp, Dept Obstet & Gynecol, Kaohsiung 804, Taiwan
[5] Kaohsiung Chang Gung Mem Hosp, Dept Obstet & Gynecol, Kaohsiung 833, Taiwan
关键词
neutralizing antibody; COVID-19; vaccine; pregnancy; cord blood; Delta variant; maternal immunity; MATERNAL IMMUNIZATION; PROTECTION; INFECTION; MOTHER; RISK;
D O I
10.3390/vaccines10010101
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy could result in adverse perinatal outcome. Clinical data on the assessment of the immune response in vaccinated pregnant women and subsequent transplacental antibody transfer are quite limited. Objective: To assess maternal and neonatal neutralizing antibody levels against both wildtype and Delta (B.1.617.2) variants after maternal mRNA vaccination. Study Design: This cohort study was conducted 29 pregnant women who were vaccinated at least one dose of Moderna (mRNA-1273) vaccine. Both neutralizing antibody (wildtype and Delta variant) and S1 receptor binding domain IgG antibody levels were evaluated in maternal and cord blood on the day of delivery. Results: Superiority of antibody level was significant in fully vaccinated women compared with the one-dose group (maternal sera, median, 97.46%; cord sera, median, 97.37% versus maternal sera, median, 4.01%; cord sera, median, 1.44%). No difference in antibody level was noted in relation to interval of second immunization to delivery in the two-dose group (95.99% in 0-2 weeks, 97.45% in 2-4 weeks, 97.48% in 4-8 weeks, 97.72% in 8-10 weeks). The most pronounced reduction was observed for the Delta variant. The wildtype neutralizing antibody level of full-vaccinated women was not influenced by the pertussis vaccination. Conclusion: The data underscore the importance of full vaccination in pregnancy and support the recommendation of COVID-19 immunization for pregnant women. The lower level of vaccine-induced neutralizing antibodies for the Delta variant indicates insufficient protection for mother and newborn and highlights the need for development of effective vaccine strategies.
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页数:12
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