Analytical techniques used to study the degradation of proteins and peptides: physical instability

被引：24

作者：

Reubsaet, JLE ^{[1
]}

Beijnen, JH ^{[1
]}

Bult, A ^{[1
]}

van Maanen, RJ ^{[1
]}

Marchal, JAD ^{[1
]}

Underberg, WJR ^{[1
]}

机构：

[1] Univ Utrecht, Fac Pharm, Dept Pharmaceut Anal, NL-3508 TB Utrecht, Netherlands

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1998年 / 17卷 / 6-7期

关键词：

analytical techniques; proteins; peptides; physical instability;

D O I：

10.1016/S0731-7085(98)00064-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The physical instability of proteins and peptides as well as the various analytical techniques used to study the various aspects of physical instability have been reviewed. Physical instability of proteins and peptides involve changes in secondary, tertiary and quaternary structures of these compounds. After a general introduction of the subject the literature data of these changes and their analytical aspects have been summarized in a Table. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

引用

页码：979 / 984

页数：6

共 44 条

[1] THE MASS-SPECTROMETRY OF HELICAL UNFOLDING IN PEPTIDES [J].

ANDEREGG, RJ ;

WAGNER, DS ;

STEVENSON, CL ;

BORCHARDT, RT .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1994, 5 (05) :425-433

[2] THE THERMAL-DENATURATION OF STEM BROMELAIN IS CONSISTENT WITH AN IRREVERSIBLE 2-STATE MODEL [J].

ARROYOREYNA, A ;

HERNANDEZARANA, A .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1995, 1248 (02) :123-128

[3] THERMALLY-INDUCED DENATURATION OF LYOPHILIZED BOVINE SOMATOTROPIN AND LYSOZYME AS IMPACTED BY MOISTURE AND EXCIPIENTS [J].

BELL, LN ;

HAGEMAN, MJ ;

MURAOKA, LM .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1995, 84 (06) :707-712

[4]

BUNSTER M, 1994, MED SCI RES, V22, P785

[5] ETHANOL UNFOLDS FIREFLY LUCIFERASE WHILE COMPETITIVE INHIBITORS ANTAGONIZE UNFOLDING - DSC AND FTIR ANALYSES [J].

CHIOU, JS ;

UEDA, I .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1994, 12 (08) :969-975

[6]

CLELAND JL, 1993, CRIT REV THER DRUG, V10, P307

[7] ELECTROPHORETIC ANALYSIS OF THE UNFOLDING OF PROTEINS BY UREA [J].

CREIGHTON, TE .

JOURNAL OF MOLECULAR BIOLOGY, 1979, 129 (02) :235-264

[8] INTERDOMAIN INTERACTIONS IN THE CHIMERIC PROTEIN TOXIN SCD4(178)-PE40 - A DIFFERENTIAL SCANNING CALORIMETRY (DSC) STUDY [J].

DAVIO, SR ;

KIENLE, KM ;

COLLINS, BE .

PHARMACEUTICAL RESEARCH, 1995, 12 (05) :642-648

[9] FUNCTIONAL-SIGNIFICANCE OF SYMMETRICAL VERSUS ASYMMETRICAL GROEL-GROES CHAPERONIN COMPLEXES [J].

ENGEL, A ;

HAYERHARTL, MK ;

GOLDIE, KN ;

PFEIFER, G ;

HEGERL, R ;

MULLER, S ;

DASILVA, ACR ;

BAUMEISTER, W ;

HARTL, FU .

SCIENCE, 1995, 269 (5225) :832-836

[10] CLASSIFICATION OF ACID DENATURATION OF PROTEINS - INTERMEDIATES AND UNFOLDED STATES [J].

FINK, AL ;

CALCIANO, LJ ;

GOTO, Y ;

KUROTSU, T ;

PALLEROS, DR .

BIOCHEMISTRY, 1994, 33 (41) :12504-12511

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