Vesicle Fusion Triggered by Optically Heated Gold Nanoparticles

被引：62

作者：

Rorvig-Lund, Andreas ^{[1
]}

Bahadori, Azra ^{[1
,2
]}

Semsey, Szabolcs ^{[1
]}

Bendix, Poul Martin ^{[1
]}

Oddershede, Lene B. ^{[1
,2
]}

机构：

[1] Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, Lundbeck Fdn Ctr Excellence Biomembranes Nanomed, DK-2100 Copenhagen, Denmark

来源：

NANO LETTERS | 2015年 / 15卷 / 06期

关键词：

vesicle; fusion; nanoparticle; Optical trap; I-BAR; GUV; INDUCED CELL-FUSION; MEMBRANE-FUSION; TRAPPING RANGE; MOBILITY; BILAYERS;

D O I：

10.1021/acs.nanolett.5b01366

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Membrane fusion can be accelerated by heating that causes membrane melting and expansion. We locally heated the membranes of two adjacent vesicles by laser irradiating gold nanoparticles, thus causing vesicle fusion with associated membrane and cargo mixing. The mixing time scales were consistent with diffusive mixing of the membrane dyes and the aqueous content. This method is useful for nanoscale reactions as demonstrated here by I-BAR protein-mediated membrane tubulation triggered by fusion.

引用

页码：4183 / 4188

页数：6

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