The Effect of Resveratrol Supplementation on Cardio-Metabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, Double-Blind Controlled Trial

被引：40

作者：

Abdollahi, Shima ^{[1
,2
,3
]}

Salehi-Abargouei, Amin ^{[1
,2
]}

Toupchian, Omid ^{[3
]}

Sheikhha, Mohammad Hasan ^{[4
,5
]}

Fallahzadeh, Hossein ^{[6
]}

Rahmanian, Masoud ^{[7
]}

Tabatabaie, Mahtab ^{[1
,2
]}

Mozaffari-Khosravi, Hassan ^{[1
,7
]}

机构：

[1] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran

[2] Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran

[3] North Khorasan Univ Med Sci, Sch Publ Hlth, Dept Nutr & Publ Hlth, Bojnurd, Iran

[4] Shahid Sadoughi Univ Med Sci, Sch Med, Dept Genet, Yazd, Iran

[5] Shahid Sadoughi Univ Med Sci, Yazd Clin & Res Ctr Infertil, Yazd, Iran

[6] Shahid Sadoughi Univ Med Sci, Dept Biostat & Epidemiol, Res Ctr Prevent & Epidemiol Noncommunicable Dis, Sch Hlth, Yazd, Iran

[7] Shahid Sadoughi Univ Med Sci, Yazd Diabet Res Ctr, Yazd, Iran

来源：

PHYTOTHERAPY RESEARCH | 2019年 / 33卷 / 12期

基金：

美国国家科学基金会;

关键词：

resveratrol; type 2 diabetes mellitus; blood glucose; body composition; INDUCED INSULIN-RESISTANCE; SKELETAL-MUSCLE; SIRT1; EXPRESSION; OBESITY; MELLITUS; METAANALYSIS; ACTIVATION; MECHANISMS; RECEPTOR; GLUCOSE;

D O I：

10.1002/ptr.6487

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aim of the present randomized controlled trial was to evaluate the effect of a micronized resveratrol supplement on glycemic status, lipid profile, and body composition in patients with type 2 diabetes mellitus (T2DM). A total of 71 overweight patients with T2DM (body mass index ranged 25-30) were randomly assigned to receive 1000 mg/day trans-resveratrol or placebo (methyl cellulose) for 8 weeks. Anthropometric indices and biochemical indices including lipid and glycemic profile were measured before and after the intervention. In adjusted model (age, sex, and baseline body mass index), resveratrol decreased fasting blood sugar (-7.97 +/- 13.6 mg/dL, p=0.05) and increased high density lipoprotein (3.62 +/- 8.75 mg/dL, p=0.01) levels compared with placebo. Moreover, the mean difference in insulin levels reached significance (-0.97 +/- 1.91, mu IU/mL, p= 0.02). However, no significant differences were observed for anthropometric measures. It was found that 8-week resveratrol supplementation produced useful effects on some cardio-metabolic parameters in patients with T2DM. More studies are needed to confirm these findings.

引用

页码：3153 / 3162

页数：10

共 75 条

[1] Validation of a new self-report instrument for measuring physical activity [J].