Autofluorescence methods in ophthalmology

An overview of the fluorophores of the eye, the methods used to measure ocular fluorescence, and the existing or ready-to-market instrumentation for the early diagnosis and monitoring of ophthalmic pathologies is presented. Emphasis is given to the impact that a more detailed knowledge of the fluorophores of the eye, their age and pathology relationship, and the considerable technology-driven progress in optical devices and components has had on the development of new compact yet powerful instruments for population screening and for patient follow-ups, using fluorometry alone or in combination with other optical techniques such as light scattering. (C) 2004 Society of Photo-Optical Instrumentation Engineers.