Cascade process mediated by left hippocampus and left superior frontal gyrus affects relationship between aging and cognitive dysfunction

被引：11

作者：

Kokudai, Yumika ^{[1
]}

Honma, Motoyasu ^{[1
]}

Masaoka, Yuri ^{[1
]}

Yoshida, Masaki ^{[2
]}

Sugiyama, Haruko ^{[3
]}

Yoshikawa, Akira ^{[1
,4
]}

Koiwa, Nobuyoshi ^{[5
]}

Kubota, Satomi ^{[1
]}

Iizuka, Natsuko ^{[1
]}

Wada, Sayaka ^{[1
]}

Kamijo, Shotaro ^{[1
]}

Uchida, Yuki ^{[1
]}

Yano, Satoshi ^{[6
]}

Ida, Masahiro ^{[7
]}

Ono, Kenjiro ^{[8
]}

Izumizaki, Masahiko ^{[1
]}

机构：

[1] Showa Univ, Dept Physiol, Sch Med, Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428555, Japan

[2] Jikei Univ, Dept Ophthalmol, Sch Med, Tokyo, Japan

[3] Kao Corp, Sensory Sci Res, Tolvo, Japan

[4] Showa Univ, Sch Nursing & Rehabil Sci, Yokohama, Kanagawa, Japan

[5] Univ Human Arts & Sci, Human Arts & Sci Res Ctr, Saitama, Japan

[6] Showa Univ, Dept Med, Div Neurol, Sch Med, Tokyo, Japan

[7] Ebara Tokyo Hosp, Stroke Ctr, Dept Radiol, Tokyo, Japan

[8] Kanazawa Univ, Dept Neurol & Neurobiol Aging, Grad Sch Med Sci, Kanazawa, Ishikawa, Japan

来源：

BMC NEUROSCIENCE | 2021年 / 22卷 / 01期

关键词：

Cognitive dysfunction; Wisconsin card sorting test; Aging; Hippocampus; Superior frontal gyrus; CARD SORTING TEST; SURFACE-BASED ANALYSIS; HUMAN CEREBRAL-CORTEX; AGE; SEGMENTATION; METAANALYSIS; PERFORMANCE; LATERALITY; THICKNESS; EPILEPSY;

D O I：

10.1186/s12868-021-00680-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background Cognitive function declines with age and has been shown to be associated with atrophy in some brain regions, including the prefrontal cortex. However, the details of the relationship between aging and cognitive dysfunction are not well understood. Methods Across a wide range of ages (24- to 85-years-old), this research measured the gray matter volume of structural magnetic resonance imaging data in 39 participants, while some brain regions were set as mediator variables to assess the cascade process between aging and cognitive dysfunction in a path analysis. Results Path analysis showed that age affected the left hippocampus, thereby directly affecting the left superior frontal gyrus. Furthermore, the gyrus directly affected higher order flexibility and maintenance abilities calculated as in the Wisconsin card sorting test, and the two abilities affected the assessment of general cognitive function. Conclusion Our finding suggests that a cascade process mediated by the left hippocampus and left superior frontal gyrus is involved in the relationship between aging and cognitive dysfunction.

引用

页数：8

共 49 条

[1] Cognitive reserve and brain maintenance in aging and dementia: An integrative review [J].

Alvares Pereira, Gabriela ;

Silva Nunes, Maria Vania ;

Alzola, Patricia ;

Contador, Israel .

APPLIED NEUROPSYCHOLOGY-ADULT, 2022, 29 (06) :1615-1625

[2] Flexible spatial learning requires both the dorsal and ventral hippocampus and their functional interactions with the prefrontal cortex [J].

Avigan, Philip D. ;

Cammack, Katharine ;

Shapiro, Matthew L. .

HIPPOCAMPUS, 2020, 30 (07) :733-744

[3] Wisconsin Card Sorting Test scores and clinical and sociodemographic correlates in Schizophrenia: multiple logistic regression analysis [J].

Banno, Masahiro ;

Koide, Takayoshi ;

Aleksic, Branko ;

Okada, Takashi ;

Kikuchi, Tsutomu ;

Kohmura, Kunihiro ;

Adachi, Yasunori ;

Kawano, Naoko ;

Iidaka, Tetsuya ;

Ozaki, Norio .

BMJ OPEN, 2012, 2 (06)

[4] Neurocognitive deficits and prefrontal cortical atrophy in patients with schizophrenia [J].

Bonilha, Leonardo ;

Molnar, Chris ;

Horner, Michael D. ;

Anderson, Berry ;

Forster, Lauren ;

George, Mark S. ;

Nahas, Ziad .

SCHIZOPHRENIA RESEARCH, 2008, 101 (1-3) :142-151

[5]

BOONE KB, 1993, J CLIN PSYCHOL, V49, P54, DOI 10.1002/1097-4679(199301)49:1<54::AID-JCLP2270490108>3.0.CO

[6]

2-6

[7] Cortical thickness is linked to executive functioning in adulthood and aging [J].

Burzynska, Agnieszka Z. ;

Nagel, Irene E. ;

Preuschhof, Claudia ;

Gluth, Sebastian ;

Baeckman, Lars ;

Li, Shu-Chen ;

Lindenberger, Ulman ;

Heekeren, Hauke R. .

HUMAN BRAIN MAPPING, 2012, 33 (07) :1607-1620

[8] Cortical surface-based analysis - I. Segmentation and surface reconstruction [J].

Dale, AM ;

Fischl, B ;

Sereno, MI .

NEUROIMAGE, 1999, 9 (02) :179-194

[9] The Wisconsin Card Sorting Test: Theoretical Analysis and Modeling in a Neuronal Network [J].

Dehaene, Stanislas ;

Changeux, Jean-Pierre .

CEREBRAL CORTEX, 1991, 1 (01) :62-79

[10] An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest [J].

Desikan, Rahul S. ;

Segonne, Florent ;

Fischl, Bruce ;

Quinn, Brian T. ;

Dickerson, Bradford C. ;

Blacker, Deborah ;

Buckner, Randy L. ;

Dale, Anders M. ;

Maguire, R. Paul ;

Hyman, Bradley T. ;

Albert, Marilyn S. ;

Killiany, Ronald J. .

NEUROIMAGE, 2006, 31 (03) :968-980

← 1 2 3 4 5 →