Biotransformation of taxol

被引：11

作者：

Chen, TS ^{[1
]}

Li, XH

Bollag, D

Liu, YC

Chang, CJ

机构：

[1] Merck Res Labs, Rahway, NJ 07065 USA

[2] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(01)00557-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioconversion of taxol/cephalomannine by Streptomyces sp. MA 7065 resulted in hydroxylation on the 10-acetyl ethyl group in 60% yield and on the benzene ring at the para position of the phenylisoserine side chain in 10% yield. This culture could also hydroxylate the allylic methyl group of the phenylisoserine side chain of cephalomannine quantitatively. All three metabolites were cytotoxic toward human lung, breast and colon tumor cell lines. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3787 / 3789

页数：3

共 14 条

[1]

FARINA V, 1995, CHEM PHARM TAXOL ITS

[2]

Georg G I., 1995, Taxane Anticancer Agents: Basic Science and Current Status

[3] ISOLATION, STRUCTURAL DETERMINATION, AND BIOLOGICAL-ACTIVITY OF 6-ALPHA-HYDROXYTAXOL, THE PRINCIPAL HUMAN METABOLITE OF TAXOL [J].