Exploring Overlaps Between the Genomic and Environmental Determinants of LVH and Stroke A Multicenter Study in West Africa

被引：8

作者：

Adeoye, Abiodun M. ^{[1
]}

Ovbiagele, Bruce ^{[2
]}

Kolo, Philip ^{[3
]}

Appiah, Lambert ^{[4
]}

Aje, Akinyemi ^{[5
]}

Adebayo, Oladimeji ^{[5
]}

Sarfo, Fred ^{[4
]}

Akinyemi, Joshua ^{[1
]}

Adekunle, Gregory ^{[1
]}

Agyekum, Francis ^{[6
]}

Shidali, Vincent ^{[7
]}

Ogah, Okechukwu ^{[5
]}

Lackland, Dan ^{[2
]}

Gebregziabher, Mulugeta ^{[2
]}

Arnett, Donna ^{[8
]}

Tiwari, Hemant K. ^{[9
]}

Akinyemi, Rufus ^{[9
]}

Olagokek, Ojo Olakanmi ^{[5
]}

Oguntade, Ayodipupo Sikiru ^{[5
]}

Olunuga, Taiwo ^{[10
]}

Uwanruochi, Kelechi ^{[11
]}

Jenkins, Carolyn ^{[2
]}

Adadey, Patrick ^{[6
]}

Iheonye, Henry ^{[7
]}

Owolabi, Lukman ^{[12
]}

Obiako, Reginald ^{[7
]}

Akinjopo, Samuel ^{[5
]}

Armstrong, Kevin ^{[2
]}

Akpalu, Albert ^{[6
]}

Fakunle, Adekunle ^{[1
]}

Saulson, Raelle ^{[2
]}

Aridegbe, Mayowa ^{[13
]}

Olowoyo, Paul ^{[14
]}

Osaigbovo, Godwin ^{[15
]}

Akpalu, Josephine ^{[6
]}

Fawale, Bimbo ^{[16
]}

Adebayo, Philip

Arulogun, Oyedunni ^{[1
]}

Ibinaiye, Philip ^{[7
,17
]}

Agunloye, Atinuke ^{[1
]}

Ishaq, Naser ^{[12
]}

Wahab, Kolawole ^{[3
]}

Akpa, Onoja ^{[1
]}

Adeleye, Omisore ^{[16
]}

Bock-Oruma, Andrew ^{[18
]}

Ogbole, Godwin ^{[1
]}

Melikam, Sylvia ^{[1
]}

Yaria, Joseph ^{[5
]}

Ogunjimi, Luqman ^{[5
]}

Salaam, Abdul ^{[15
]}

机构：

[1] Univ Ibadan, Ibadan, Nigeria

[2] Med Univ South Carolina, Charleston, SC 29425 USA

[3] Univ Ilorin, Teaching Hosp, Ilorin, Nigeria

[4] Komfo Anokye Teaching Hosp, Kumasi, Ghana

[5] Univ Coll Hosp, Ibadan, Nigeria

[6] Univ Ghana, Med Sch, Accra, Ghana

[7] Ahmadu Bello Univ, Zaria, Nigeria

[8] Univ Kentucky, Lexington, KY USA

[9] Univ Alabama Birmingham, Birmingham, AL USA

[10] Fed Med Ctr, Abeokuta, Nigeria

[11] Fed Med Ctr, Umuahia, Niger

[12] Aminu Kano Teaching Hosp, Kano, Nigeria

[13] Sacred Heart Hosp, Abeokuta, Nigeria

[14] Fed Univ Teaching Hosp, Ido Ekiti, Nigeria

[15] Jos Univ, Teaching Hosp, Jos, Nigeria

[16] Obafemi Awolowo Univ, Teaching Hosp, Ife, Nigeria

[17] Ladoke Akintola Univ Technol, Ogbomosho, Nigeria

[18] Delta State Univ, Teaching Hosp, Ogara, Nigeria

[19] Fed Med Ctr, Owo, Nigeria

来源：

GLOBAL HEART | 2017年 / 12卷 / 02期

基金：

美国国家卫生研究院;

关键词：

LEFT-VENTRICULAR HYPERTROPHY; ANGIOTENSIN-CONVERTING ENZYME; ISCHEMIC-STROKE; GENE POLYMORPHISMS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; WIDE ASSOCIATION; NORTHERN SWEDEN; HEALTH-WORKERS; RISK-FACTORS;

D O I：

10.1016/j.gheart.2017.01.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Whether left ventricular hypertrophy (LVH) is determined by similar genomic and environmental risk factors with stroke, or is simply an intermediate stroke marker, is unknown. Objectives: We present a research plan and preliminary findings to explore the overlap in the genomic and environmental determinants of LVH and stroke among Africans participating in the SIREN (Stroke Investigative Research and Education Network) study. Methods: SIREN is a transnational, multicenter study involving acute stroke patients and age-,ethnicity-, and sex-matched control subjects recruited from 9 sites in Ghana and Nigeria. Genomic and environmental risk factors and other relevant phenotypes for stroke and LVH are being collected and compared using standard techniques. Results: This preliminary analysis included only 725 stroke patients (mean age 59.1 +/- 13.2 years; 54.3% male). Fifty-five percent of the stroke subjects had LVH with greater proportion among women ( 51.6% vs. 48.4%; p < 0.001). Those with LVH were younger (57.9 +/- 12.8 vs. 60.6 +/- 13.4; p = 0.006) and had higher mean systolic and diastolic blood pressure (167.1/99.5 mm Hg vs 151.7/90.6 mm Hg; p < 0.001). Uncontrolled blood pressure at presentation was prevalent in subjects with LVH (76.2% vs. 57.7%; p < 0.001). Significant independent predictors of LVH were age < 45 years (adjusted odds ratio [AOR]: 1.91; 95% confidence interval [CI]: 1.14 to 3.19), female sex (AOR: 2.01; 95% CI: 1.44 to 2.81), and diastolic blood pressure > 90 mm Hg (AOR: 2.10; 95% CI: 1.39 to 3.19; p < 0.001). Conclusions: The prevalence of LVH was high among stroke patients especially the younger ones, suggesting a genetic component to LVH. Hypertension was a major modifiable risk factor for stroke as well as LVH. It is envisaged that the SIREN project will elucidate polygenic overlap (if present) between LVH and stroke among Africans, thereby defining the role of LVH as a putative intermediate cardiovascular phenotype and therapeutic target to inform interventions to reduce stroke risk in populations of African ancestry.

引用

页码：107 / +

页数：12

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