The Clinical Significance of RMI2 in Hepatocellular Carcinoma

被引:2
作者
Zheng, Bin [1 ,2 ]
Wang, Heng [1 ]
Wang, Jin-Xue [3 ]
Liu, Zheng-Hong [2 ]
Zhang, Pu [1 ]
Zhang, Dahong [1 ,2 ]
机构
[1] Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Hangzhou 310014, Peoples R China
[2] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China
[3] Han Dan Cent Hosp, Handan, Peoples R China
关键词
RMI2; hepatocellular carcinoma; immunohistochemistry; bioinformatics; prognosis; survival;
D O I
10.1177/15330338211045496
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Hepatocellular carcinoma (HCC), which is the most common type of primary liver cancer, often presents at advanced stage with a dismal prognosis. Novel tumor biomarkers are needed to aid in HCC early detection and prognostication. Methods: Immunohistochemical staining for RecQ-mediated genome instability protein 2 (RMI2) was performed in 330 surgically resected HCC specimens and 190 adjacent normal tissues. Univariate and multivariate regression analysis were applied to identify prognostic indicators of HCC outcomes. Patient's survival was assessed with the Kaplan-Meier method. Results: RMI2 in HCC tissue was significantly higher than that in adjacent normal tissues, and was positively correlated with HCC histological grade and stage (P < .05) but negatively correlated with the survival period. RIM2 was identified to be an independent prognostic indicator for HCC. Conclusion: The abnormal expression of RMI2 may be related to the occurrence and development of HCC. RIM2 could potentially serve as a novel tumor-specific biomarker for HCC diagnosis and prognosis prediction.
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页数:6
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