What are the benefits of moderate weight loss?

Obesity is associated with increased morbidity and mortality. The condition, and central obesity in particular, is linked to a number of disorders including glucose intolerance, insulin resistance, hyperinsulinaemia, hypertension, dyslipidaemia, impaired fibrinolysis, atherosclerosis, gall bladder disease, some cancers and osteoarthritis. Weight loss therefore benefits the individual by reducing health risks and improving the quality of life. A body mass index (BMI) of around 22 kg/m(2) is related to a minimal risk of mortality compared with higher BMI values. An extensive review of clinical studies has shown the clear benefits of moderate weight loss (5-10% of baseline body weight). Thus in obese individuals for whom a substantial weight loss is not feasible, moderate weight loss should be encouraged.